| Effect of high-dose etodolac on renal function. | |
| | |
MedLine Citation:
|
PMID: 2957139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous studies from our laboratory have demonstrated transient effects on renal function by etodolac, 200 mg b.i.d. The current study assessed the effects of a larger dose of etodolac (500 mg b.i.d.) to explore the time course of its renal effects and to determine whether the transient effect would become more prolonged with a larger dose. We studied 10 normal subjects and nine patients with renal insufficiency, examining the effects of the first 500 mg dose of etodolac as well as 4 days of b.i.d. administration. In both groups, etodolac transiently decreased fractional excretions of sodium and chloride and urinary prostaglandin E2. In patients, etodolac also transiently decreased inulin and para-aminohippuric acid clearances and urinary 6-keto-prostaglandin F1 alpha. Chronic administration caused no changes in renal function in either group. In summary, in this relatively small group of patients, high-dose etodolac caused only transient, fully reversible effects on renal function, the cumulative effect of which was negligible. |
| | |
Authors:
|
D C Brater; D Brown-Cartwright; S A Anderson; M Uaamnuichai |
Related Documents
:
|
6694109 - Renal transport of netilmicin in the rat. 2527539 - Pharmacokinetics of cilazapril in patients with renal failure. 2458109 - Effects of arotinolol on hemodynamics and adrenergically induced renin release and rena... 2104499 - Effect of free radicals in ischaemic renal failure in the dog. 17635499 - The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist,... 543899 - Pharmacokinetics of azlocillin in children with cystic fibrosis. 16423479 - Analgesic and anticonvulsant effects of extracts from the leaves of kalanchoe crenata (... 3430729 - Systemic and coronary hemodynamic effects of beta-adrenoceptor blocking agents in coron... 8482649 - Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in th... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Clinical pharmacology and therapeutics Volume: 42 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1987 Sep |
Date Detail:
|
Created Date: 1987-10-22 Completed Date: 1987-10-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 283-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
6-Ketoprostaglandin F1 alpha
/
urine Acetic Acids / pharmacology* Adult Aged Aldosterone / blood Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Body Weight / drug effects Dinoprostone Etodolac Humans Kidney / drug effects, physiology, physiopathology* Middle Aged Potassium / blood Prostaglandins E / urine Reference Values Renin / blood Sodium / urine |
| Grant Support | |
ID/Acronym/Agency:
|
AM00705/AM/NIADDK NIH HHS; AM27059/AM/NIADDK NIH HHS; RR00633/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Acetic Acids; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Prostaglandins E; 363-24-6/Dinoprostone; 41340-25-4/Etodolac; 52-39-1/Aldosterone; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevention of the complications of scoliosis by early detection.
Next Document: Clinical pharmacology of trimetrexate.