| Effect of high dose ergocalciferol in chronic kidney disease patients with 25-hydroxyvitamin D deficiency. | |
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MedLine Citation:
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PMID: 20718162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate 25 hydroxyvitamin D (25-OH-D) deficiency in a cohort ofpredialysis CKD patients and the treatment effect and safety of high dose ergocalciferol supplement in predialysis CKD. MATERIAL AND METHOD: Fifty-six predialysis CKD patients who came for a regular visit at a single hospital with calculated glomerular filtration rate < or =60 mL/min/1.73 m2 were screened for 25-OH-D levels. Forty-four patients with 25-OH-D deficiency were recruited into this prospective observational study that examined the effect of high dose oral ergocalciferol supplementation. After eight weeks, 37 patients completed the follow-up and biochemical parameters were reevaluated and analyzed. RESULTS: The mean 25-OH-D level of 56 patients was 25.6 +/- 8 ng/mL. Forty-four (78.5%) patients had 25-OH-D levels less than 30 ng/mL and four (7.1%) had severe deficiency with the level less than 15 ng/mL. High dose ergocalciferol supplement successively increased 25-OH-D levels in 35 (95%) patients. 25-OH-D levels increased significantly from 22 +/- 4.8 to 34.5 +/- 10.8 ng/mL after eight weeks (p < 0.001). During the study period, there were no changes in serum calcium, phosphate, and PTH. There was no other side effect associated with the treatment. CONCLUSION: 25-OH-D deficiency were found in this cohort of predialysis CKD patients. Ergocalciferol was a safe and effective supplement for the 25-OH-D in predialysis CKD. |
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Authors:
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Thananda Trakarnvanich; Oran Chalapipat; Sinee Disthabanchong; Sathit Kurathong; Kearkiat Praditpornsilpa; Wasana Stitchantrakul; La-Or Chailurkit |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 93 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 885-91 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department ofMedicine, BMA Medical college and Vajira Hospital, Bangkok, Thailand. thananda@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Calcium / blood Dose-Response Relationship, Drug Ergocalciferols / therapeutic use* Female Follow-Up Studies Humans Kidney Failure, Chronic / blood*, complications, physiopathology Male Middle Aged Parathyroid Hormone / blood Phosphorus / blood Prospective Studies Renal Dialysis / adverse effects* Treatment Outcome Vitamin D Deficiency / blood, complications, drug therapy* Vitamins / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Ergocalciferols; 0/Parathyroid Hormone; 0/Vitamins; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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