Document Detail

Effect of high concentrations of cAMP on proliferative activity of V79-1A cells.
MedLine Citation:
PMID:  6293894     Owner:  NLM     Status:  MEDLINE    
We studied the mechanisms of the inhibitory effect of high cAMP concentrations on growth of Chinese hamster V79-1A cells. High cAMP concentrations inhibit growth of V79-1A cells in the S phase of the cell cycle. The inhibition is probably due to some effect on the metabolism of DNA precursors. We suggest that this inhibition is not induced by the cyclic nucleotide itself, but by AMP as a degradation product of cAMP.
J Kovár
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia biologica     Volume:  28     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  1982  
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  295-301     Citation Subset:  IM    
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MeSH Terms
Bucladesine / pharmacology*
Cell Cycle / drug effects*
Cell Line
Cyclic AMP / metabolism*
DNA Replication / drug effects
Protein Biosynthesis
Theophylline / pharmacology
Reg. No./Substance:
362-74-3/Bucladesine; 58-55-9/Theophylline; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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