Document Detail

Effect of a high carbohydrate, low sodium and low fat diet in type 2 diabetics with moderate hypertension.
MedLine Citation:
PMID:  3011689     Owner:  NLM     Status:  MEDLINE    
The effect of an intended diet, high in cereal fibre, low in fat and sodium was assessed over a 3-month period in 13 type 2 diabetic patients with moderate hypertension (diastolic blood pressure greater than 105 and less than 115 mmHg without antihypertension drug therapy). Eleven patients completed the study and two patients were withdrawn owing to an increase of blood pressure above initial values after 1 month. Using a compliance scoring system by an observer unaware of blood pressure response, patients were divided into those compliant to the dietary regimen (n = 7; group A) and those who were not, and therefore were considered controls (n = 4; group B). Group A demonstrated significant reductions in systolic (190.4 +/- 18 to 166.6 +/- 22.4 mmHg; P less than 0.02) and diastolic blood pressure (113.1 +/- 3.7 to 103.3 +/- 9.1 mmHg; P less than 0.01), weight (78.5 +/- 5.6 to 74.3 +/- 6.8 kg; P less than 0.02), daily urinary sodium excretion (210.3 +/- 79.9 to 120.3 +/- 56.1 mmol; P less than 0.02) and serum LDL levels (P less than 0.02). A reduction in glycosylated haemoglobin of 2.2 per cent was also noted. Three patients achieved a diastolic blood pressure level below 100 mmHg. In contrast, no significant changes occurred in group B. In particular, systolic and diastolic blood pressure (111.0 +/- 2.2 to 110.3 +/- 8.9 mmHg) remained unchanged. We conclude that the modified diet may have a hypotensive effect in diabetic subjects with moderate hypertension. However, the degree of blood pressure reduction suggests that this diet could, at best, only be considered an adjunct to conventional antihypertensive drug therapy.
P J Pacy; P M Dodson; R F Fletcher
Related Documents :
8731109 - Urinary kallikrein: a marker of blood pressure sensitivity to salt.
1128229 - Relationships of the renin-angiotensin-aldosterone system and sodium balance to blood p...
3241259 - Effect of potassium supplementation combined with dietary sodium reduction on blood pre...
2096199 - Casual urine concentrations of sodium, potassium, and creatine in population studies of...
3475419 - Blood pressure regulation on low and high sodium diets in normotensive members of normo...
2931209 - Role of sodium in hypertensive cardiac hypertrophy.
18182119 - Effect of different cuff widths on the motor nerve conduction of the median nerve: an e...
3020089 - Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension...
11505029 - Electroencephalogram spectral characteristics after alcohol ingestion in japanese men w...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity     Volume:  10     ISSN:  -     ISO Abbreviation:  Int J Obes     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-08     Completed Date:  1986-07-08     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7703240     Medline TA:  Int J Obes     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism
Body Weight
Diabetes Mellitus, Type 2 / complications*
Diet, Sodium-Restricted
Dietary Carbohydrates / administration & dosage*,  therapeutic use
Dietary Fats / administration & dosage*,  therapeutic use
Dietary Fiber / administration & dosage*,  therapeutic use
Hypertension / blood,  diet therapy*,  etiology
Lipids / blood
Lipoproteins / blood
Middle Aged
Patient Compliance
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipids; 0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evidence against functional adenosine receptors on murine lymphocytes.
Next Document:  Synthesis of pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin and evaluation of th...