| Effect of the hepatocyte growth factor on allergic inflammatory cells. | |
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MedLine Citation:
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PMID: 20523071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocyte growth factor (HGF) has multiple activities in a variety of tissues, and is known to prevent the onset and progression of various diseases, but the mechanisms by which HGF exert its beneficial effects remain to be elucidated, although many studies have shown that HGF exerts anti-inflammatory effects in multiple animal models of diseases of the liver, kidney, lung and other organs. Recently, we have reported that HGF also reduces allergic airway inflammation in a murine model of asthma by ovalbumin. Furthermore, HGF directly modulates various functions of eosinophils, which have been shown to play a pivotal role in the development of allergic airway inflammation. HGF influences a number of cell types, and regulates various biological activities, including cytokine production, cell migration, proliferation and survival. This review focuses on the effect of HGF on various inflammatory cells, e.g. eosinophils and dendritic cells, in allergic reactions. |
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Authors:
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Wataru Ito; Masahide Takeda; Shigeharu Ueki; Tomomi Tanigai; Hiroyuki Kayaba; Junichi Chihara |
Publication Detail:
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Type: Journal Article; Review Date: 2010-06-04 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 152 Suppl 1 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 96-100 Citation Subset: IM |
Copyright Information:
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(c) 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cells / drug effects*, immunology, physiology Dendritic Cells / drug effects, immunology, physiology Eosinophils / drug effects, immunology, physiology Hepatocyte Growth Factor / pharmacology*, physiology, therapeutic use Humans Hypersensitivity / drug therapy, immunology*, pathology* |
| Chemical | |
Reg. No./Substance:
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67256-21-7/Hepatocyte Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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