Document Detail

Effect on hepatic ornithine decarboxylase of some food additives and synthetic elastomers.
MedLine Citation:
PMID:  3956794     Owner:  NLM     Status:  MEDLINE    
The food additives butylated hydroxytoluene, butylated hydroxyanisole and sodium cyclamate and the precursors for packaging materials acrylamide, acrylic acid, acrylonitrile and vinylpyrrolidone were investigated for their ability to induce hepatic ornithine decarboxylase (ODC) in vivo, in order to obtain indications about their possible tumour-promoting activities. It was shown that butylated hydroxyanisole, acrylonitrile, vinylpyrrolidone and acrylamide have the capacity to increase rat liver ODC activity, while butylated hydroxytoluene, acrylic acid and sodium cyclamate did not affect ODC activity.
L Van de Zande; R Kunnen; B Uijtewaal; R Van Wijk; A Bisschop
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives and contaminants     Volume:  3     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:    1986 Jan-Mar
Date Detail:
Created Date:  1986-05-20     Completed Date:  1986-05-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
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MeSH Terms
Enzyme Induction / drug effects
Food Additives / pharmacology*
Liver / drug effects,  enzymology*
Ornithine Decarboxylase / biosynthesis*
Plastics / pharmacology*
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
0/Food Additives; 0/Plastics; EC Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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