| Effect of hepatic blood inflow occlusion without hemihepatic artery control on apoptosis of liver cells in rats. | |
| | |
MedLine Citation:
|
PMID: 20422868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: To investigate the effect of hepatic blood inflow occlusion without hemihepatic artery control on the apoptosis of liver cells during ischemia-reperfusion injury in rats. METHODOLOGY: Animal models of three hepatic vascular occlusion methods were established. Hepatic blood inflow occlusion without hemihepatic artery control (WH group), hemihepatic vascular occlusion (HH group) and Pringle maneuver (PR group) were compared. RESULTS: At each time point after reperfusion, ALT, AST, and apoptosis rates were significantly higher in the PR group than in the HH group or the WH group (p < 0.01), and the pathology and hepatocyte ultrastructure at 6 hours after reperfusion were significantly worse in the PR group than in the HH group or the WH group (p < 0.01). ALT, AST, apoptosis rate, pathology and hepatocyte ultrastructure at 6 hours after reperfusion were not significantly different between the WH group and the HH group (p > 0.05). CONCLUSION: Hepatic blood inflow occlusion without hemihepatic artery control can reduce hepatic ischemia-reperfusion injury, and the effect is similar to that of hemihepatic vascular occlusion. |
| | |
Authors:
|
Shan Jin; Chaoliu Dai; Yuntian Yang; Ruiming Zhang; A Sileng |
Related Documents
:
|
1474858 - Relationship between endothelin and thromboxane a2 in rat liver microcirculation. 10896368 - Trauma- and sepsis-induced hepatic ischemia and reperfusion injury: role of angiotensin... 9530188 - Hepatic venular resistance responses to norepinephrine, isoproterenol, adenosine, hista... 6150818 - Kinetics of meperidine n-demethylation in the perfused rat liver preparation. 2229798 - Intracardiac shunting in children with ventricular septal defect: evaluation with doppl... 8869868 - Influence of the mechanism of regurgitation on the quantification of mitral regurgitati... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Hepato-gastroenterology Volume: 57 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2010 Jan-Feb |
Date Detail:
|
Created Date: 2010-04-28 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
|
Languages: eng Pagination: 35-40 Citation Subset: IM |
Affiliation:
|
Department of General Surgery, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, China. altten_aull@yahoo.com.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis Constriction Disease Models, Animal Dissection Hemostasis, Surgical Hepatectomy / adverse effects, methods* Hepatic Artery* Hepatocytes / pathology*, ultrastructure Portal Vein* Rats Rats, Wistar Reperfusion Injury / etiology, pathology*, prevention & control* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical outcome of metachronous hepatic metastases secondary to gastric cancer.
Next Document: Combined resection and radiofrequency ablation for bilobar colorectal cancer liver metastases.