Document Detail

Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery.
Jump to Full Text
MedLine Citation:
PMID:  19668591     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the influence of irrigation of the anterior chamber with heparin sodium on postoperative inflammation after pediatric cataract surgery.
SETTING: Kartal Training and Research Hospital, First Eye Clinic, Istanbul, Turkey.
DESIGN: Randomized prospective double-blind study.
METHODS: Fourteen consecutive eyes from 14 patients aged 8.9 +/- 5.9 years, (range 3-18 years) (group 1) and 19 eyes from 19 patients aged 9.1 +/- 5.2 (range 1.5-18 years) (group 2) underwent pediatric cataract surgery. Five patients in group 1 were between three and five years old. One patient was 1.5 years old and six patients in group 2 were between three and five years old. During the procedure, group 1 received anterior chamber irrigation with heparin sodium (5 IU/cc) and 1 ml of heparin sodium (concentration 10 IU/ml) added to the irrigating balanced salt solution (BSS Plus; Alcon Laboratories, Inc., Fort Worth, TX, USA) while group 2 received BSS without heparin sodium only. Cases aged under three years received anterior vitrectomy in addition to posterior capsulorrhexis. One eye received anterior vitrectomy in group 1 and two eyes received anterior vitrectomy in group 2. Cases with preoperative complications were not included in the study. Early and late postoperative inflammatory complications, including fibrin formation, anterior and posterior synechia, cyclitic and pupillary membrane formation were recorded and compared.
RESULTS: Mild anterior chamber reaction was observed in three patients in Group 1, while nine cases in group 2 experienced marked anterior chamber reaction. In four of nine patients from group 2, anterior chamber reaction was severe and resulted in pupillary membrane and synechia despite treatment in the postoperative 7th day, while in all three cases in group 1, reaction disappeared by the 7th day.
CONCLUSION: Anterior chamber irrigation with heparin during pediatric cataract surgery may minimize early inflammatory reaction and decrease the number of postoperative inflammatory related complications.
Authors:
Yelda B Ozkurt; Arzu Taşkiran; Nadire Erdogan; Baran Kandemir; Omer K Doğan
Publication Detail:
Type:  Journal Article     Date:  2009-06-29
Journal Detail:
Title:  Clinical ophthalmology (Auckland, N.Z.)     Volume:  3     ISSN:  1177-5467     ISO Abbreviation:  Clin Ophthalmol     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-11     Completed Date:  2011-05-26     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  101321512     Medline TA:  Clin Ophthalmol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  363-5     Citation Subset:  -    
Affiliation:
Department of Ophthalmology, Kartal Training and Research Hospital, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Clin Ophthalmol
Journal ID (publisher-id): Clinical Ophthalmology
ISSN: 1177-5467
ISSN: 1177-5483
Publisher: Dove Medical Press
Article Information
Download PDF
? 2009 ?zkurt et al, publisher and licensee Dove Medical Press Ltd.
License:
Received Day: 16 Month: 6 Year: 2009
collection publication date: Year: 2009
Print publication date: Year: 2009
Electronic publication date: Day: 29 Month: 6 Year: 2009
Volume: 3 Issue:
First Page: 363 Last Page: 365
ID: 2709035
PubMed Id: 19668591
Publisher Id: opth-3-363

Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
Yelda B ?zkurt
Arzu Ta?k?ran
Nadire Erdogan
Baran Kandemir
?mer K Do?an
Department of Ophthalmology, Kartal Training and Research Hospital, Istanbul, Turkey
Correspondence: Correspondence: Yelda ?zkurt, Korkut sokak, Dumankaya evleri, A1B blok, ?en apartman?, 9/7, Kozyata?, Istanbul, Turkey, Tel +90 216 4164352, Email yeldaozkurt@yahoo.com

Pediatric cataract surgery may result in preoperative and postoperative complications.1 Cataract surgery and other intraocular procedures have a higher incidence and more pronounced postoperative inflammatory reactions in children compared with adults.1 These reactions are associated with younger age and may be affected by surgical technique, intraoperative injury to adjacent structures such as iris, presence of antecedent ocular infection, and remnants of retained cortical material.1 Heparin has anti-inflammatory and antiproliferative effects in addition to its anticoagulant function,2 inhibits fibrin formation after intraocular surgery, and has also been shown to inhibit fibroblast activity.3

In this prospective study, we evaluated the influence of anterior chamber irrigation with heparin sodium on early postoperative inflammation and cellular reaction after pediatric cataract surgery.


Patients and methods

Fourteen eyes from 14 pediatric cataract cases aged 8.9 ? 5.9 years (group 1: range 3?18 years) received anterior chamber irrigation with heparin sodium (5 IU/cc) during operation and received 1 ml of heparin sodium (concentration 10 IU/ml) added to the irrigating solution of BSS (BSS Plus) whilst in 19 eyes from 19 pediatric cataract cases aged 9.1 ? 5.2 (group 2: range 1.5?18 years), BSS without heparin sodium was used.

All patients had no ocular pathology other than cataract. The parents were asked to sign an informed consent for the procedure. All children underwent cataract extraction under general anesthesia by two experienced surgeons. After a 3.2-mm limbal tunnel incision was created, the anterior chamber was entered, and a continuous curvilinear capsulorrhexis (CCC) was made with the Utrata forceps. The size of anterior capsulorrhexis was between 5.0 mm and 5.5 mm. After the nucleus was hydrodissected, lens material was aspirated using the automated irrigation/aspiration mode of the phacoemulsifier after the hydrodissection. All cases received posterior capsulorrhexis with a diameter of 3.5 mm and 4.0 mm. One eye received anterior vitrectomy in group 1 and two eyes received anterior vitrectomy in group 2. Cases aged under three years received anterior vitrectomy in addition to posterior capsulorrhexis. One eye received anterior vitrectomy in group 1 and two eyes received anterior vitrectomy in group 2.

All eyes having intraocular lens (IOL) implantation received monoblock, hydrofobic foldable acrylic IOL (AcrySof MA30BA; Alcon Laboratories, Inc.). Cases with peroperative complications were not included in the study. No oral or subconjunctival steroids were used. Standardized postoperative treatment comprised prednisolone acetate 1% (Pred Forte?; Allergan, Inc., Irvine, CA, USA) eight times a day for one week followed by six times a day for the second week and tapered over six weeks, and ciprofloxacin 0.3% (Ciloxan; Alcon Laboratories, Inc.) and and ketorolac 0.5% three times a day for one month. All patients were followed daily for the first three days, once a week for the first month, and at the 3rd and 6th months. At all visits, postoperative intraocular complications, including fibrin formation, anterior and posterior synechia, cyclitic and pupillary membrane formation, and posterior capsular opacification (PCO) were recorded and compared. The follow-up period after surgery was between three and 24 months (average 9.4 months = ?7.15). The Fisher?s exact test was used for statistical analysis.


Results

The two groups were comparable in age and distribution of sex (Student t-test p > 0.05). There were no statistically significant differences between the two groups. Table 1 shows preoperative and postoperative patient data in groups 1 and 2. Mild anterior chamber reaction was observed in only three patients in group 1, while nine cases of group 2 experienced marked anterior chamber reaction. In four of nine patients from group 2, anterior chamber reaction was severe which resulted in pupillary membrane and synechia, despite treatment on the postoperative 7th day (Table 2).

In two of these four cases, synechiatomy was performed as a second surgical procedure. In the long-term follow up in two cases from group 2, pupillary irregularity was reported. It was seen that anterior chamber reaction disappeared in all three cases of group 1 on the 7th day and pupillary irregularity was not reported in any of these cases. Hyphema or intraocular hemorrhage due to heparin were not reported in any cases in both groups. Differences found between the group 1 and the group 2 could have occurred by chance or because of the small size of the studied population.


Discussion

The pathogenesis of postoperative fibrinoid inflammation is unknown. Any defect in the blood?aqueous barrier (BAB), possibly due to intraocular inflammation, preoperative high intraocular pressure (IOP), or excessive eye manipulation during surgery may lead to a disturbance in the coagulation and fibrinolytic pathway.4

A tendency towards increased postoperative inflammation in children is well recognized.5 Intraocular inflammation manifests itself as increased cells and flare, inflammatory precipitates on the IOL and the endothelium, formation of synechia, and inflammatory cyclitic membranes.1 The fibrinoid reaction after pediatric cataract surgery is caused by the breakdown of the immature BAB and insufficient trabecular meshwork fibrinolytic activity.6 Secondary complications of severe fibrinoid reaction include papillary membrane and opacification of the anterior hyaloid face.6 Therefore, measures that may prevent or decrease inflammation in these eyes deserve consideration.7 In addition to its well-known anticoagulant activity, heparin has anti-inflammatory and antiproliferative properties.6 Heparin inhibits fibrin formation after intraocular surgery and has also been shown to inhibit fibroblast activity.3

Due to its antithrombin effect, heparin inhibits fibrin formation by accelerating the control mechanisms for thrombin and activated X-factor.8

Previous studies elucidate several mechanisms through which heparin may inhibit inflammation including induction of apoptosis in human peripheral blood neutrophils, inhibition of the complement activation and lymphocyte migration, L- and P-selectin, adhesion-molecule support of the initial attachment of leukocytes to the vessel wall at the inflammation sie, neutrophil chemotaxis, and generation of refractive oxygen species by mononuclear and polymorphonuclear leukocytes.1,4,6 Another useful adjunct for the prevention of membrane formation over the IOL optic is the use of a heparin-coated IOL.

In our study of pediatric cataract surgery, addition of heparin to the irrigating BSS prevented postoperative inflammatory complications. In this study it was shown that in heparin sodium-added group 1 patients, early postoperative inflammatory reactions were rare. Bayramlar and colleagues6 concluded that the addition of heparin to the irrigating solution during surgery decreases postoperative fibrinoid reaction and late inflammatory complications.

The incidence of PCO after pediatric cataract surgery has been reported as high as 95.8%.9 Several studies demonstrated the antiproliferative effect of heparin on lens epithelial cells and its additive effect to prevent PCO in children. In our study, in the 6th month, PCO was reported in only one case from group 1 and in four cases from group 4.

Hyphema, which can be seen during surgery due to heparin irrigation, was not seen in our study. However, this risk can also be diminished by using low molecular weight heparin.8 Iverson and colleagues suggest that fragmin, at a concentration of 5 IU/mL, lowers the risk of hemorrhage during vitreoretinal and lensectomy surgeries.10.

Our results suggest that adding heparin sodium to the irrigating solution seems to be a safe, effective, and promising method to prevent early postoperative inflammatory reactions and PCO formation in the long term after pediatric cataract surgery.


Notes

Disclosure

The authors report no conflicts of interest in this work.

References
1.. Rumelt S,Stolovich C,Segal ZI,Rehany U. Intraoperative enoxaparin minimizes inflammatory reaction after pediatric cataract sutgeryAm J OphthalmolYear: 200614143343716490487
2.. Kruger A,Amon M,Formanek CA,Schild G,Kolodjaschna J,Schauersberger J. Effect of heparin in the irrigation solution on postoperative inflammation and cellular reaction on the intraocular lens surfaceJ Cataract Refract SurgYear: 200228879211777715
3.. Dada T. Intracameral heparin in pediatric cataract surgeryJ Cataract Refract SurgYear: 200329105612842660
4.. Mehta JS,Adams GG. r-TPA following pediatric cataract surgeryBr J OphthalmolYear: 20008498398610966949
5.. Basti S,Aasuri M,Reddy MK,Preetam P,Reddy S,Gupta S,Naduvilath T. Heparin-surface-modified intraocular lenses in paediatric cataract surgery: prospective randomized studyJ Cataract Refract SurgYear: 19992578278710374157
6.. Bayramlar H,Totan Y,Borazan M. Heparin in the intraocular irrigating solution in pediatric cataract surgeryJ Cataract Refract SurgYear: 2004302163216915474831
7.. Wilson ME,Trivedi RH. Low molecular-weight heparin in the intraocular irrigating solution in pediatric cataract and intraocular lens surgeryAm J OpthalmolYear: 2006141537538
8.. Johnson RN,Blankenship G. A prospective, randomized clinical trial of heparin therapy for postoperative intraocular fibrinOphthalmologyYear: 1988953123173173998
9.. Knight-Nanan D,O?Keefe M,Bowell R. Outcome and complications of intraocular lenses in children with cataractJ Cataract Refract SurgYear: 1996227307368844387
10.. Iverson D,Katsura H,Hartzer MK,et al. Inhibition of intraocular fibrin formation following infusion of low-molecular-weight heparin during vitrectomyArch OphthalmolYear: 19911044054092003803

Article Categories:
  • Original Research

Keywords: pediatric, cataract, surgery, inflammation.

Previous Document:  Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel catara...
Next Document:  Phakic anterior chamber intraocular lens (Verisyse) implantation in children for treatment of severe...