Document Detail

Effect of hemorrhagic shock on the performance, O2-consumption, and ultrastructure of isolated rat hearts.
MedLine Citation:
PMID:  7389064     Owner:  NLM     Status:  MEDLINE    
Rat hearts were isolated from control animals anesthetized and sham treated for 2.5 hours and following 2.5 hours of hemorrhagic hypotension and they were perfused by modified Langendorff technique. Hearts isolated following hemorrhagic hypotension exhibited increased coronary resistance, depressed left ventricular mechanical performance, and significantly increased sensitivity to threefold elevation of perfusate Ca2+ (from 1.3 to 3.9 mM). Electron microscopic examination showed increased permeability of the plasma membrane for lanthanum, zonal lesions of contractile filaments, damage of mitochondria, and dilation of T-tubules and sarcoplasmic reticulum. Experimental results indicate that myocardial damage is of hypoxic/ischemic origin during the procedure used as a model for shock. Mechanical failure of postoligemic hearts may be caused by the combination of zonal lesions of the myofilaments, damage of energy production, and impairment of cellular calcium metabolism.
G Rubányi; A G Kovách; E Koltay; T Nagy-Dóra; I Balogh; E Somogyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  7     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-70     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Energy Metabolism
Myocardium / ultrastructure*
Oxygen Consumption*
Pentobarbital / pharmacology
Shock, Hemorrhagic / physiopathology*
Time Factors
Vascular Resistance
Reg. No./Substance:
7439-91-0/Lanthanum; 7440-70-2/Calcium; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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