| Effect of hemorrhagic hypotension and hypoventilation on lower esophageal sphincter pressure. | |
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MedLine Citation:
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PMID: 7406564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dysfunction of the lower esophageal sphincter has been demonstrated in the cat shock model. Analogies have been drawn to reflux and aspiration in the critically ill patient. In a cat shock model, lower esophageal sphincter pressure is reduced and response to bethanechol is impaired. Upon resuscitation to basal state with heparinized shed blood, the lower esophageal basal pressure returns to normal values, and response to bethanechol is restored. This model may explain reflux and aspiration in the critically ill patient. |
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Authors:
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L K LiCalzi; P Biancani; J Behar; M D Kerstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of surgery Volume: 192 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-10-24 Completed Date: 1980-10-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 53-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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physiopathology Animals Anoxia / physiopathology Bethanechol Compounds / therapeutic use Bloodletting Cats* Disease Models, Animal* Esophagogastric Junction / physiopathology* Gastroesophageal Reflux / etiology* Hydrogen-Ion Concentration Hypercapnia / physiopathology Hypotension / drug therapy, physiopathology* Hypoventilation / drug therapy, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Bethanechol Compounds |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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