Document Detail

Effect of hemolysis on oxygen and hematocrit measurements by near infrared reflectance spectroscopy.
MedLine Citation:
PMID:  11996849     Owner:  NLM     Status:  MEDLINE    
A short review of the principles of near infrared reflectance spectroscopy (NIRS) in whole blood is followed by a discussion on the influence of hemolysis. The increase of free plasmahemoglobin (PHb) has a strong influence on the continuous measurement of hematocrit and oxygen saturation (O(2)S) by NIRS. In view of the relative stability of hematocrit values in vivo this effect may be used to detect a change of the hemolysis rate induced by blood pumps in case of malfunction. The aim of this study is, therefore, the assessment of the hemolysis rate within an in vitro mock loop comprising a rotary blood pump by means of NIRS at constant hematocrit levels compared to the photometric reference method. Reflected light is measured by an integrated optical sensor working at three wavelengths (660 nm, 730 nm, and 830 nm). The experimental results demonstrate that the increase of free hemoglobin in plasma due to mechanical pumping leads to a decrease of detected reflected light at all three wavelengths. Influencing parameters such as adhering proteins on the sensor surface and the blood flow rate are briefly discussed. Finally, the possibility of using NIRS sensors for detecting malfunctions of blood pumps in vitro and in vivo is discussed, together with the option of using these sensors for supervision of long-term implantable pumps.
F Neudel; S Takatani; H Reul; G Rau
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Medical engineering & physics     Volume:  24     ISSN:  1350-4533     ISO Abbreviation:  Med Eng Phys     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-11-06     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Helmholtz-Institute for Biomedical Engineering, Department of Cardiovascular Engineering, Pauwelsstr. 20, 52074 Aachen, Germany.
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MeSH Terms
Biosensing Techniques / instrumentation,  methods
Equipment Design
Hematocrit / instrumentation,  methods*
Hemoglobinometry / instrumentation,  methods
Hemoglobins / analysis*
Hemolysis / physiology*
Infrared Rays
Models, Cardiovascular
Oxygen / blood*
Scattering, Radiation
Sensitivity and Specificity
Spectroscopy, Near-Infrared / instrumentation*,  methods*
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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