| Effect of hemin on the synthesis of hemoglobin and other proteins in mammalian cells. | |
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MedLine Citation:
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PMID: 4197926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The initiation of globin synthesis in intact reticulocytes and in reticulocyte lysates is maintained by the addition of hemin. The specificity of this effect has been studied to determine whether it is restricted to hemoglobin and erythroid cells. In intact reticulocytes, hemin (500 muM) enhances the synthesis of carbonic anhydrase as well as of hemoglobin. Similar enhancement of protein synthesis is observed on addition of hemin (500 muM) to intact Krebs II ascites tumor cells, in cell-free extracts of these cells, added hemin (50 muM) increases endogenous protein synthesis and the translation of exogenous rabbit globin messenger RNA. These results provide evidence that the effect of hemin is not restricted to globin, and they suggest that hemin may enhance protein synthesis in at least some nonerythroid cells. |
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Authors:
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Y Beuzard; R Rodvien; I M London |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 70 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1973 Apr |
Date Detail:
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Created Date: 1973-09-12 Completed Date: 1973-09-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1022-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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metabolism Animals Carbon Isotopes Carbonic Anhydrases / biosynthesis*, isolation & purification Carcinoma, Krebs 2 Cell Line Chromatography Chromatography, Ion Exchange Electrophoresis, Polyacrylamide Gel Globins / biosynthesis, isolation & purification Heme / pharmacology* Hemoglobins / biosynthesis*, isolation & purification Neoplasm Proteins / biosynthesis Protein Biosynthesis / drug effects RNA, Messenger / metabolism Rabbits Reticulocytes / drug effects, enzymology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Hemoglobins; 0/Neoplasm Proteins; 0/RNA, Messenger; 14875-96-8/Heme; 56-41-7/Alanine; 9004-22-2/Globins; EC 4.2.1.1/Carbonic Anhydrases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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