| Effect of hematocrit on the washout of xenon and iodantipyrine from dog myocardium. | |
| | |
MedLine Citation:
|
PMID: 856485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The rates of washout of 133Xe and 131I-iodoantipyrine from the myocardium into the coronary sinus blood were determined over a wide range of hematocrits after simultaneous injection of the isotopes into the left anterior descending coronary artery of dogs. The ratio of the monoexponential disappearance constants (kX/kI), which is a measure of the ratio of the dynamic blood-tissue partition coefficients (lambdabIX/lambdabtI), increases linearly with hematocrit. This dynamic lambdabt ratio has almost the same relationship to hematocrit as the static lambdabt ratio. By the use of appropriate hemotocrit-specific lambdabt values, we found that simultaneous blood flows calculated from the two indicators with different disappearance constants showed excellent agreement. If this hematocrit-dependent alteration in indicator partitioning is neglected, blood flow measurement in the dog with 133Xe washout may introduce an error of approximately 1.15% per unit hematocrit deviation from the normal value (taken as 45%), whereas blood flow measurements with 131I-iodanatipyrine washout had negligible errors. |
| | |
Authors:
|
R Carlin; S Chien |
Related Documents
:
|
8167295 - Intraoperative perfusion echocardiography. 8416335 - Platelet adhesion/aggregation in an in vitro model of coronary artery stenosis. 3552315 - Interpretation of changes in coronary flow that accompany pharmacologic interventions. 10410825 - Beta-adrenergic blockade decreases coronary collateral blood flow in patients with coro... 9496765 - Flow resistance of airways under hyperbaric conditions. 9238795 - First-pass radionuclide angiography in the diagnosis of aortoiliac thromboembolism in a... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation research Volume: 40 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1977 May |
Date Detail:
|
Created Date: 1977-06-11 Completed Date: 1977-06-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 505-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antipyrine / analogs & derivatives, metabolism* Coronary Circulation Dogs Hematocrit* Iodine Radioisotopes Myocardium / metabolism* Xenon Radioisotopes / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Iodine Radioisotopes; 0/Xenon Radioisotopes; 60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of the antibiotic ionophore X-537A on contractility and ionic exchange in rabbit ventricular...
Next Document: High-performance liquid chromatography of pyruvic and alpha-ketoglutaric acids and its application t...