| Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients. | |
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MedLine Citation:
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PMID: 21411767 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Besides dyspnea relief, an improvement in locomotor muscle oxygen delivery may also contribute to enhanced exercise tolerance following normoxic heliox administration in patients with chronic obstructive pulmonary disease (COPD). Whether blood flow redistribution from intercostal to locomotor muscles contributes to this improvement, currently remains unknown. Accordingly, the objective of this study was to investigate whether such redistribution plays a role in improving locomotor muscle oxygen delivery whilst breathing heliox at near-maximal [75% peak work rate (WR(peak))], maximal (100%WR(peak)) and supra-maximal (115%WR(peak)) exercise in COPD. Intercostal and vastus lateralis muscle perfusion was measured in ten COPD patients by near-infrared spectroscopy using indocyanine green dye. Patients undertook exercise tests at 75 and 100%WR(peak) breathing either air or heliox and at 115%WR(peak) breathing heliox only. Normoxic heliox reduced respiratory muscle work and relieved dyspnea across all exercise intensities. During near-maximal exercise, quadriceps and intercostal muscle blood flows were greater whilst breathing normoxic heliox compared to air [(mean±SEM) 35.8±7.0 versus 29.0±6.5, and 6.0±1.3 versus 4.9±1.2 ml/min/100gr,respectively;p<0.05]. In addition, compared to air, heliox administration increased arterial oxygen content, as well as oxygen delivery to quadriceps and intercostal muscles (from 47±9 to 60±12, and from 8±1 to 13±3 mlO2/min/100gr,respectively;p<0.05). In contrast, heliox had neither an effect on systemic nor on quadriceps or intercostal muscle blood flow and oxygen delivery during maximal or supra-maximal exercise. Since intercostal muscle blood flow did not decrease by heliox administration, blood flow redistribution from intercostal to locomotor muscles does not represent a likely mechanism of improvement in locomotor muscle oxygen delivery. |
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Authors:
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Ioannis Vogiatzis; Helmut Habazettl; Andrea Aliverti; Dimitris Athanasopoulos; Zafeiris Louvaris; Antonella Lomauro; Harrieth E Wagner; Charis Roussos; Peter D Wagner; Spyros G Zakynthinos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Athens. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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