Document Detail

Effect of heat stress on 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine absorption measured in vitro.
MedLine Citation:
PMID:  1437977     Owner:  NLM     Status:  MEDLINE    
The objective of the present experiments was to determine the biochemical basis for preliminary chick performance data, which indicate an ameliorative effect of 2-hydroxy-4-(methylthio)butanoic acid (HMB) when compared with DL-methionine (DLM) fed during hot conditions. In vitro passage of HMB or DLM across intact segments of small intestine from either control (thermoneutral, TN) or heat-stressed (HS) birds was used as a model for intestinal absorption. For DLM placed in the lumen, appearance in the outside buffer was reduced when using intestine from HS birds compared with tissue from TN birds. In contrast, the appearance of HMB in the outside buffer was greater using HS intestine, resulting in a substrate by environment interaction (P < .01). Slices of everted small intestine from TN and HS birds were used to study epithelial uptake of methyl labeled 14C-DLM by three transport pathways: diffusion, carrier-specific energy- and sodium-independent uptake (ESI), and carrier-specific energy- and sodium-dependent uptake (ESD). Correcting for extracellular volume, total epithelial uptake of 14C-DLM (diffusion plus ESI plus ESD) was reduced by 34% in HS intestine (P < .05). Energy-dependent uptake was observed to decrease by 87% in HS (P < .05). Energy-independent uptake was increased (136%, HS versus TN, P < .05), but not enough to compensate for the decrease in ESD uptake. Intestinal transport systems for glucose and leucine were also observed to change during HS, suggesting a role for cellular transport changes in the performance reduction associated with HS.
J J Dibner; C A Atwell; F J Ivey
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  71     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1900-10     Citation Subset:  IM    
Novus International, Inc., Chesterfield, Missouri 63198.
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MeSH Terms
Chickens / metabolism*
Hot Temperature / adverse effects*
Intestinal Absorption
Intestine, Small / metabolism
Methionine / analogs & derivatives*,  pharmacokinetics*
Poultry Diseases / metabolism
Stress, Physiological / metabolism,  veterinary
Reg. No./Substance:
583-91-5/alpha-hydroxy-gamma-methylmercaptobutyric acid; 63-68-3/Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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