Document Detail

Effect of halothane on diaphragmatic muscle function in pentobarbital-anesthetized dogs.
MedLine Citation:
PMID:  3946805     Owner:  NLM     Status:  MEDLINE    
The mechanism underlying the decrease in minute ventilation (VE) observed under halothane anesthesia was investigated in nine spontaneously breathing dogs. Anesthesia was induced with pentobarbital sodium and was maintained with halothane. Inspired fraction of halothane (FIhal) was increased every 30 min, from 0.005 to 0.02. VE decreased from 8.1 +/- 0.9 to 4.8 +/- 0.4 l . min-1 (P less than 0.001), as FIhal increased from 0 to 0.02. This resulted from a decrease in both mean inspiratory flow (VT/TI) and the duty ratio (TI/TTOT). Transdiaphragmatic pressure (Pdi) and the integrated electrical activity of both hemidiaphragms (Edi) were measured during normal breathing, and during breathing against closed airways (P0di, E0di), in order to obtain an index of the inspiratory neuromuscular output of the diaphragm. With increasing FIhal, there was a significant decrease in Pdi, P0di, Edi, and E0di. The authors measured Pdi and Edi generated during supramaximal stimulation of the two phrenic nerves (PSdi, Esdi) at frequencies of 10, 20, 50, and 100 Hz, in order to eliminate in this decrease the role played by a decrease in the neural drive to breathing. PSdi and ESdi decreased significantly with increasing FIhal, and had not returned to the control values 30 min after discontinuation of halothane administration. The authors conclude that, in pentobarbital-anesthetized dogs, halothane is responsible for a diaphragmatic dysfunction, which may be located either at the neuromuscular junction, on the contractile processes of the muscle, or on both, and for a decrease in the activation time of the inspiratory muscles. Both of these effects contribute to the decrease in VE observed under halothane anesthesia.
F Clergue; N Viires; P Lemesle; M Aubier; P Viars; R Pariente
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  64     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-05     Completed Date:  1986-03-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  AIM; IM    
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MeSH Terms
Diaphragm / drug effects*
Dose-Response Relationship, Drug
Halothane / pharmacology*
Inspiratory Capacity
Muscle Contraction / drug effects
Neuromuscular Junction / drug effects
Respiration / drug effects
Tidal Volume
Time Factors
Reg. No./Substance:
151-67-7/Halothane; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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