Document Detail

Effect of halothane on critical levels of oxygen transport in the anesthetized newborn lamb.
MedLine Citation:
PMID:  3111309     Owner:  NLM     Status:  MEDLINE    
A critical level of oxygen transport has been defined as the level which is required to maintain tissue oxygen uptake (VO2). If halothane reduces the susceptibility to hypoxia, it should lower the critical levels of both O2 delivery (DO2) and arterial oxygen tension (pO2). To test this hypothesis, 12 newborn lambs were anesthetized with either fentanyl and pancuronium (control group) or fentanyl, pancuronium, and 1.1% (1 MAC) halothane (halothane group). Baseline measurements of hemoglobin, cardiac output (CO), arterial and mixed-venous pO2, and saturation were obtained on FIO2 1.0, and repeated with FIO2 .21, .15, and .10. O2 delivery (CO X CaO2) and O2 consumption were calculated from measured parameters. Critical levels were selected using a system of repetitive linear regression. Halothane decreased baseline O2 consumption (12.1 +/- 0.7 to 8.4 +/- 0.4 cc X kg-1 X min-1, x +/- SEM, P less than .001, unpaired t test), but caused similar reductions in cardiac output (235 +/- 15 to 132 +/- 15 cc X kg-1 X min-1, P less than .001) and O2 delivery (29.2 +/- 2.9 to 20.2 +/- 1.6 cc X kg-1 X min-1, P less than .05). Addition of halothane decreased the critical level of O2 delivery from 17.9 to 14.3 cc X kg-1 X min-1, but had no effect on the critical level of arterial pO2 (control group, 47 mmHg halothane, 46 mmHg). Peripheral oxygen utilization was mildly reduced during halothane anesthesia, as evidenced by a decrease in oxygen extraction (control group O2 extraction rate = 0.63; halothane group O2 extraction = 0.51, P less than .05, unpaired t test).(ABSTRACT TRUNCATED AT 250 WORDS)
M B Hershenson; P P O'Rourke; J A Schena; R K Crone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  67     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-24     Completed Date:  1987-08-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  174-9     Citation Subset:  AIM; IM    
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MeSH Terms
Animals, Newborn / metabolism*
Carbon Dioxide / blood
Cardiac Output / drug effects
Halothane / pharmacology*
Oxygen / blood
Oxygen Consumption / drug effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 151-67-7/Halothane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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