Document Detail

Effect of hair color and sun sensitivity on nevus counts in white children in Colorado.
MedLine Citation:
PMID:  20584558     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been widely reported that individuals with a light phenotype (ie, light hair color, light base skin color, and propensity to burn) have more nevi and are at greater risk for developing skin cancer. No studies have systematically investigated how phenotypic traits may interact in relation to nevus development.
OBJECTIVE: We sought to systematically examine whether any combinations of phenotype are associated with a greater or lesser risk for nevus development in white children.
METHODS: In the summer of 2007, 654 children were examined to determine full body nevus counts, skin color by colorimetry, and hair and eye color by comparison with charts. Interviews of parents were conducted to capture sun sensitivity, sun exposure, and sun protection practices.
RESULTS: Among 9-year-old children with sun sensitivity rating type II (painful burn/light tan), those with light hair had lower nevus counts than did those with dark hair (P value for interaction = .03). This relationship was independent of eye color, presence of freckling, sex, usual daily sun exposure, sunburn in 2004 to 2007, sun protection index, and waterside vacation sun exposure. The difference in nevus counts was further determined to be specific to small nevi (<2 mm) and nevi in intermittently exposed body sites.
LIMITATIONS: Geographic and genetic differences in other study populations may produce different results.
CONCLUSION: The standard acceptance that dark phenotype is a marker for low melanoma risk and light phenotype a marker for high risk may need to be reevaluated. In non-Hispanic white children, dark-haired individuals who burn readily and then tan slightly are more prone to nevus development, and may therefore be a previously underrecognized high-risk group for melanoma.
Jenny Aalborg; Joseph G Morelli; Tim E Byers; Stefan T Mokrohisky; Lori A Crane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-26
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  63     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-10-13     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  430-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Age Distribution
Cohort Studies
Colorado / epidemiology
Dermatitis, Photoallergic / epidemiology,  genetics*
European Continental Ancestry Group / genetics*
Genetic Predisposition to Disease / epidemiology*
Hair Color / genetics*
Melanoma / genetics,  prevention & control
Nevus, Pigmented / epidemiology,  genetics*
Risk Assessment
Sex Distribution
Skin Neoplasms / genetics,  prevention & control
Sunburn / epidemiology,  genetics*,  prevention & control
Sunlight / adverse effects
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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