Document Detail


Effect of haemodialysis on the control of the circulation in patients with chronic renal failure.
MedLine Citation:
PMID:  3887923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms of hypotension during haemodialysis were investigated by studying cardiovascular reflexes, body fluid volumes, and osmolality in 11 patients with renal failure before and after haemodialysis and in 17 normal subjects before and after furosemide diuresis. Blood pressure and heart rate responses to tests of autonomic nervous function were unaffected in either group except that in the patients, head-up tilt after haemodialysis caused a fall in blood pressure. This was associated with a greater fall in cardiac output than before haemodialysis but with a similar rise in peripheral vascular resistance. Resting plasma noradrenaline levels were higher than normal, and the rise in plasma noradrenaline levels in response to tilt was unaffected by haemodialysis. Plasma renin activity rose in response to head-up tilt in normal subjects, but not in patients either before or after haemodialysis. Our studies indicate that changes in plasma potassium and osmolality or the possible peripheral circulatory effects of acetate do not impair the regulation of the circulation in response to haemodialysis. Haemodialysis does not reduce plasma noradrenaline levels. Impaired myocardial function in response to fluid depletion or unresponsiveness of the renin-angiotensin system may contribute to haemodialysis hypotension.
Authors:
R B Naik; C J Mathias; J L Reid; D J Warren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of nephrology     Volume:  5     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-05-31     Completed Date:  1985-05-31     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System / physiopathology
Blood Pressure
Cardiac Output
Diuresis
Extracellular Space / drug effects
Female
Furosemide / therapeutic use
Heart Rate
Humans
Hypotension / etiology*,  physiopathology
Kidney Failure, Chronic / physiopathology*,  therapy
Male
Middle Aged
Norepinephrine / blood
Osmolar Concentration
Renal Dialysis / adverse effects*
Renin / blood
Vascular Resistance
Water-Electrolyte Balance / drug effects
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 54-31-9/Furosemide; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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