Document Detail


Effect of h-EGF and h-EGF 1-48 on histamine-stimulated gastric acid secretion in rats and monkeys.
MedLine Citation:
PMID:  8292984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of human epidermal growth factor (h-EGF) and its derivative human epidermal growth factor 1-48 (h-EGF 1-48) on histamine-stimulated gastric acid secretion was studied in monkeys and rats. In monkeys, both h-EGF and h-EGF 1-48 given intravenously (i.v.) in a stepwise manner and in doses ranging from 0.01 to 10 nmol/kg, gradually suppressed gastric acid secretion. At the highest dose tested, both compounds essentially abolished gastric acid output. In the same animals, i.v. administration of 1 nmol/kg of h-EGF or h-EGF 1-48 caused an inhibition of gastric acid output that reached a peak at 90 and 60 min after the administration of h-EGF or h-EGF 1-48 respectively. After this maximum gastric inhibitory effect, a gradual return toward pre-injection values was observed. In rats, after subcutaneous (sc) administration, both h-EGF and h-EGF 1-48 dose-dependently inhibited histamine-stimulated gastric acid output as measured 60 min after the administration of the compounds. The maximum inhibitory activity on gastric acid output, observed at a dose of 100 nmol/kg, was 74.4% and 76.0% for h-EGF and h-EGF 1-48 respectively. The same dose of both compounds, however, failed to significantly inhibit gastric acid secretion when administered orally. In all the studies h-EGF 1-48 showed activity and potency comparable to h-EGF.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A Guglietta; C A Lesch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology, Paris     Volume:  87     ISSN:  0928-4257     ISO Abbreviation:  J. Physiol. Paris     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-03     Completed Date:  1994-03-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9309351     Medline TA:  J Physiol Paris     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Affiliation:
Gastrointestinal Disorders Group, Parke-Davis Pharmaceutical Research Division, Ann Arbor, MI 48105.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epidermal Growth Factor / pharmacology*
Female
Gastric Acid / secretion*
Histamine / pharmacology
Macaca mulatta
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
51-45-6/Histamine; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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