Document Detail

Effect of guanylate cyclase-C activity on energy and glucose homeostasis.
MedLine Citation:
PMID:  24898144     Owner:  NLM     Status:  In-Data-Review    
Uroguanylin is a gastrointestinal hormone primarily involved in fluid and electrolyte handling. It has recently been reported that prouroguanylin, secreted postprandially, is converted to uroguanylin in the brain and activates the receptor guanylate cyclase-C (GC-C) to reduce food intake and prevent obesity. We tested central nervous system administration of two GC-C agonists and found no significant reduction of food intake. We also carefully phenotyped mice lacking the GC-C receptor and found them to have normal body weight, adiposity, and glucose tolerance. Interestingly, uroguanylin knockout mice had a small but significant increase in body weight and adiposity that was accompanied by glucose intolerance. Our data indicate that the modest effects of uroguanylin on energy and glucose homeostasis are not mediated by central GC-C receptors.
Denovan P Begg; Kris A Steinbrecher; Joram D Mul; Adam P Chambers; Rohit Kohli; April Haller; Mitchell B Cohen; Stephen C Woods; Randy J Seeley
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Publication Detail:
Type:  Journal Article     Date:  2014-06-04
Journal Detail:
Title:  Diabetes     Volume:  63     ISSN:  1939-327X     ISO Abbreviation:  Diabetes     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-10-24     Completed Date:  -     Revised Date:  2014-12-06    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3798-804     Citation Subset:  AIM; IM    
Copyright Information:
© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
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