Document Detail

Effect of growth hormone treatment in patients with chronic fatigue syndrome: a preliminary study.
MedLine Citation:
PMID:  10990148     Owner:  NLM     Status:  MEDLINE    
The efficacy of growth hormone (GH) therapy was evaluated in patients with chronic fatigue syndrome (CFS) who had peak serum GH levels below 10 microg/l during stage-controlled sleep. Twenty patients (7 men, 13 women; age range, 30-60 years) with CFS were randomized to receive placebo or GH therapy, 6.7 microg/kg/day (0.02 IU/kg/day), for 12 weeks. Following this double-blind treatment period, the 17 patients remaining in the study were given GH therapy at the above dose for an open period of 9 months. Mean (+/- SD) serum levels of insulin-like growth factor I (IGF-I) increased during GH treatment, from 173 +/- 46 microg/I to 296 +/- 89 microg/l (P < 0.001); IGF-I SDS values increased from -0.45 +/- 1.14 to +1.43 +/- 1.09 (P < 0.001). Fat-free mass and total body water were significantly increased after 12 months of treatment. Although quality of life, as assessed using two different questionnaires, did not improve significantly during GH treatment, four patients were able to resume work after a long period of sick leave.
G Moorkens; H Wynants; R Abs
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  8 Suppl B     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2000-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  131-3     Citation Subset:  IM    
Department of Internal Medicine, University Hospital Antwerp, Belgium.
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MeSH Terms
Body Water / drug effects
Body Weight / drug effects
Circadian Rhythm
Double-Blind Method
Fatigue Syndrome, Chronic / blood,  drug therapy*,  metabolism
Human Growth Hormone / pharmacology,  therapeutic use*
Insulin-Like Growth Factor I / metabolism
Middle Aged
Quality of Life
Skinfold Thickness
Sleep / physiology
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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