Document Detail


Effect of growth hormone replacement therapy on pituitary hormone secretion and hormone replacement therapies in GHD adults.
MedLine Citation:
PMID:  14752209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We tested the impact of commencement of GH replacement therapy in GH-deficient (GHD) adults on the circulating levels of other anterior pituitary and peripheral hormones and the need for re-evaluation of other hormone replacement therapies, especially the need for dose changes. METHODS: 22 GHD patients were investigated in a double-blind randomized study and 90 GHD patients in an open study at baseline and after 6 and 12 months of GH replacement therapy. RESULTS: In the placebo-controlled trial, the FT(3) levels increased after 6 months in the GH-treated group, and in the open study the FT(3) levels tended to increase. Other hormone concentrations did not change in either part of the study. Four patients required an increase in thyroxine dose, while 2 patients needed dose reduction. One originally euthyroid patient required thyroxine replacement. Two patients with originally conserved pituitary-adrenal function developed ACTH insufficiency. The hydrocortisone dose was increased in 1 and decreased in 1 of the 66 patients with secondary hypocortisolism. None of the females required any adjustment of sex hormone replacement therapy. Two of 37 males needed dose increase of testosterone, while 1 needed dose reduction. CONCLUSION: GH replacement therapy required dose adjustments regarding other hormone replacement therapies in 12.2% (n = 11), while initiation of new hormone replacement was performed in 3.3% (n = 3) of the 90 patients during the 1-year follow-up. Monitoring of pituitary hormone axes is advisable after commencement of GH replacement therapy, since changes of hormone replacement therapy was observed in a small but clinically significant number of patients.
Authors:
Erika Hubina; Henriette Mersebach; Ase Krogh Rasmussen; Anders Juul; Simone Bjerregaard Sneppen; Miklós I Góth; Ulla Feldt-Rasmussen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2004-01-30
Journal Detail:
Title:  Hormone research     Volume:  61     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  211-7     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Affiliation:
Department of Medicine, National Medical Center, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Double-Blind Method
Female
Gonads / metabolism
Growth Hormone / therapeutic use*
Hormone Replacement Therapy*
Hormones / administration & dosage,  blood
Human Growth Hormone / deficiency*
Humans
Insulin-Like Growth Factor I / metabolism
Male
Middle Aged
Pituitary Gland / metabolism
Pituitary Hormones / secretion*
Prolactin / blood
Steroid Metabolism, Inborn Errors / blood,  drug therapy*,  metabolism*
Thyroid Gland / metabolism
Chemical
Reg. No./Substance:
0/Hormones; 0/Pituitary Hormones; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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