| Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study. | |
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MedLine Citation:
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PMID: 9322500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: The effects of parenteral growth hormone, glutamine supplementation, and a high carbohydrate-low fat (HCLF) diet on gut adaptation in short-bowel syndrome are unclear. The aim of this study was to compare effects of this treatment regimen and placebo in patients with short-bowel syndrome. METHODS: A randomized, 6-week, double-blind, placebo-controlled, crossover study in 8 patients with short-bowel syndrome (average small bowel length, 71 cm; mean duration, 12.9 years) was performed. Active treatment was growth hormone (0.14 mg.kg-1.day-1), oral glutamine (0.63 g.kg-1.day-1), and the HCLF diet for 21 days. The weight, basal metabolic rate, nutrient and electrolyte balance, serum insulin-like growth factor I levels, D-xylose absorption, morphology and DNA proliferation of small intestinal mucosa, and gastrointestinal transit were evaluated. Treatments were compared by paired t test. RESULTS: Active treatment transiently increased body weight, significantly but modestly increased the absorption of sodium and potassium, and decreased gastric emptying. The assimilation of macronutrients, stool volumes, and morphometry of small bowel mucosa were not statistically different in the two treatment arms. CONCLUSIONS: Although treatment with growth hormone, glutamine, and HCLF diet for 3 weeks resulted in modest improvements in electrolyte absorption and delayed gastric emptying, there were no improvements in small bowel morphology, stool losses, or macronutrient absorption. |
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Authors:
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J S Scolapio; M Camilleri; C R Fleming; L V Oenning; D D Burton; T J Sebo; K P Batts; D G Kelly |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 113 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1074-81 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Adult Basal Metabolism Body Weight Cross-Over Studies DNA / biosynthesis Diet, Fat-Restricted Dietary Proteins Double-Blind Method Female Food, Fortified Gastric Emptying Gastrointestinal Transit Glutamine / administration & dosage, therapeutic use* Human Growth Hormone / therapeutic use* Humans Ileostomy Insulin-Like Growth Factor I / metabolism Intestinal Absorption Intestinal Mucosa / metabolism, pathology Male Middle Aged Placebos Short Bowel Syndrome / pathology, physiopathology*, therapy* Water-Electrolyte Balance Xylose / pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
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RR00585/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Placebos; 0/Xylose; 12629-01-5/Human Growth Hormone; 56-85-9/Glutamine; 67763-96-6/Insulin-Like Growth Factor I; 9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 1997 Oct;113(4):1402-5
[PMID:
9322536
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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