Document Detail

Effect of green tea on angiogenesis and severity of atherosclerosis in cholesterol-fed rabbit.
MedLine Citation:
PMID:  16697267     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Since the development of the atherosclerotic plaque requires the growth of new microvessels in the plaque itself (vasa vasorum), we postulated that green tea may exert an anti-atherogenic effect. METHODS AND RESULTS: Thirteen male New Zealand white rabbits were studied for 17 weeks. All rabbits were fed an hypecholesterolemic diet. After 2 weeks of adaptation rabbits were randomly assigned into two groups. Animals in Group A were fed the hypercholesterolemic diet and received plain tap water ad libitum. Animals in Group B were fed with the same diet and furthermore received 2.5% (g/g) green tea for 17 weeks. CONCLUSION: According to our results the atherosclerotic lesions were more severe in Group B than in Group A specimens. Also, the number of VEGF positively stained foam cells and smooth muscle cells of Group B were significantly greater than in Group A. About 30% less plaque was found in Group A than in the control group (Group B). So, our study showed that the consumption of green tea leads to a reduction of atherosclerosis as well as a significant decrease of VEGF expression in the atherosclerotic plaque of rabbit aorta. The hypothesis that probably green tea may produce its anti-atherogenetic effect through an anti-angiogenetic mechanism needs more investigation.
N Kavantzas; A Chatziioannou; A E Yanni; D Tsakayannis; D Balafoutas; G Agrogiannis; D Perrea
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Publication Detail:
Type:  Journal Article     Date:  2006-05-11
Journal Detail:
Title:  Vascular pharmacology     Volume:  44     ISSN:  1537-1891     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-3     Citation Subset:  IM    
Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias str. Goudi-Athens GR-11527, Greece.
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MeSH Terms
Angiogenesis Inhibitors / pharmacology*,  therapeutic use
Aorta, Abdominal / drug effects*,  metabolism,  pathology
Aorta, Thoracic / drug effects*,  metabolism,  pathology
Atherosclerosis / etiology,  metabolism,  pathology,  prevention & control
Camellia sinensis*
Cholesterol, Dietary / toxicity*
Hypercholesterolemia / etiology,  metabolism,  pathology,  prevention & control
Plant Extracts / pharmacology*,  therapeutic use
Plant Leaves
Severity of Illness Index
Vascular Endothelial Growth Factor A / metabolism
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Cholesterol, Dietary; 0/Plant Extracts; 0/Vascular Endothelial Growth Factor A

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