Document Detail


Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial.
MedLine Citation:
PMID:  21766228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: This study evaluated the effect of GTP supplementation and Tai Chi (TC) exercise on serum markers of bone turnover (bone-specific alkaline phosphatase, BAP, and tartrate-resistant acid phosphatase, TRAP), calcium metabolism, and muscle strength in postmenopausal osteopenic women.
METHODS: One hundred and seventy-one postmenopausal osteopenic women were randomly assigned to four groups: (1) placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) placebo + TC (placebo plus TC training at 60 min/session, three sessions/week), and (4) GTP + TC (GTP plus TC training). Overnight fasting blood and urine samples were collected at baseline, 1, 3, and 6 months for biomarker analyses. Muscle strength was evaluated at baseline, 3, and 6 months. One hundred and fifty subjects completed the 6-month study.
RESULTS: Significant increases in BAP level due to GTP intake (at 1 month) and TC (at 3 months) were observed. Significant increases in the change of BAP/TRAP ratio due to GTP (at 3 months) and TC (at 6 months) were also observed. Significant main effect of TC on the elevation in serum parathyroid hormone level was observed at 1 and 3 months. At 6 months, muscle strength significantly improved due to GTP, TC, and GTP + TC interventions. Neither GTP nor TC affected serum TRAP, serum and urinary calcium, and inorganic phosphate.
CONCLUSION: In summary, GTP supplementation and TC exercise increased BAP and improved BAP/TRAP ratio. TC exercise increased serum parathyroid hormone. GTP supplementation, TC exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.
Authors:
C-L Shen; M-C Chyu; J K Yeh; Y Zhang; B C Pence; C K Felton; J-M Brismée; B H Arjmandi; S Doctolero; J-S Wang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-07-16
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  23     ISSN:  1433-2965     ISO Abbreviation:  Osteoporos Int     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-20     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1541-52     Citation Subset:  IM    
Affiliation:
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, Lubbock, TX 79430-9097, USA. Leslie.Shen@ttuhsc.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00625391
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Bone Diseases, Metabolic / blood,  physiopathology,  therapy*
Bone Remodeling / drug effects,  physiology
Calcium / metabolism
Combined Modality Therapy
Dietary Supplements
Double-Blind Method
Female
Humans
Middle Aged
Muscle Strength / physiology
Osteoporosis, Postmenopausal / prevention & control
Parathyroid Hormone / blood
Patient Compliance
Phytotherapy / methods*
Placebos
Plant Extracts / therapeutic use
Polyphenols / therapeutic use
Tai Ji*
Tea*
Grant Support
ID/Acronym/Agency:
1R21AT003735-01A1/AT/NCCAM NIH HHS; R21 AT003735-01A1/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Parathyroid Hormone; 0/Placebos; 0/Plant Extracts; 0/Polyphenols; 0/Tea; 7440-70-2/Calcium
Comments/Corrections

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