Document Detail

Effect of gravity on lung exhaled nitric oxide at rest and during exercise.
MedLine Citation:
PMID:  9108629     Owner:  NLM     Status:  MEDLINE    
Exhaled nitric oxide (NO) from the lungs (VNO) in nose-clipped subjects increases during exercise. This may be due to endothelial shear stress secondary to changes in pulmonary blood flow. We measured VNO after modifying pulmonary blood flow with head-out water immersion (WI) or increased gravity (2 Gz) at rest and during exercise. Ten sedentary males were studied during exercise performed in air and WI. Nine subjects were studied at 1 and 2 Gz. Resting NO concentrations in exhaled air ([NO]) were 16.3 +/- 8.2 ppb (air). 15 +/- 8.2 ppb (WI) and 17.4 +/- 5 ppb (2 Gz). VNO (ppb/min) was calculated as [NO]VE and was unchanged at rest by either WI or 2 Gz. VNO increased linearly with Vo2, VE and fii during exercise in air, WI and at 2 Gz. These relationships did not differ among the experimental conditions. Therefore, changes in pulmonary blood flow failed to alter the output of NO exhaled from the lungs at rest or during exercise.
S Pogliaghi; J A Krasney; D R Pendergast
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  107     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-26     Completed Date:  1997-06-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM; S    
Hermann Rahn Laboratory of Environmental Physiology, Department of Physiology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences 14214, USA.
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MeSH Terms
Exercise / physiology*
Heart Rate / physiology
Immersion / physiopathology
Lung / metabolism*,  physiology
Nitric Oxide / metabolism*
Oxygen Consumption / physiology
Pulmonary Alveoli / metabolism
Pulmonary Circulation / physiology
Rest / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide
D R Pendergast / SUNY, Buffalo

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