Document Detail

Effect of gradual accumulation of iron, molybdenum and sulfur, slow depletion of zinc and copper, ethanol or fructose ingestion and phlebotomy in gout.
MedLine Citation:
PMID:  10616042     Owner:  NLM     Status:  MEDLINE    
Gout affects mostly males over 40 years old and, occasionally, postmenopausal women. This pattern coincides with the pattern of iron accumulation. On the other hand, menstruating women are seldom afflicted by gout, because the monthly blood loss causes them to accumulate iron to a much lesser degree. Gout involves seven aspects: (1) uric acid overproduction from increased purines in the diet; (2) uric acid overproduction from ATP degradation; (3) uric acid overproduction from increased de novo synthesis of purines; (4) uric acid overproduction from increased DNA breakdown from cell damage; (5) decreased uric acid elimination, caused by molybdenum and sulfur binding to copper in the kidneys; (6) precipitation of sodium urate-iron crystals in the joints due to high ferritin and saturated transferrin and low CuZn-SOD and Cu-thionein in the joint; (7) development of inflammation, triggered by tyrosine bonding to the sodium-urate-iron crystals and being transformed by tyrosine kinase. Alcohol and iron greatly affect most of these aspects. Therefore, phlebotomy is suggested as therapy for gout patients, in order to eliminate the accumulated Fe. Furthermore, yearly blood donation is recommended for males with a family history of gout, so as to prevent Fe accumulation and avoid gout.
S Johnson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  53     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  407-12     Citation Subset:  IM    
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MeSH Terms
Copper / deficiency
Ethanol / administration & dosage*
Fructose / administration & dosage*
Gout / etiology*,  metabolism,  prevention & control,  therapy
Iron / metabolism
Kidney / metabolism
Metals / metabolism*
Molybdenum / metabolism*
Sulfur / metabolism*
Zinc / deficiency
Reg. No./Substance:
0/Metals; 30237-26-4/Fructose; 64-17-5/Ethanol; 7439-89-6/Iron; 7439-98-7/Molybdenum; 7440-50-8/Copper; 7440-66-6/Zinc; 7704-34-9/Sulfur

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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