Document Detail

Effect of graded hypoxia on cortical and spinal somatosensory evoked potentials.
MedLine Citation:
PMID:  1631759     Owner:  NLM     Status:  MEDLINE    
Cortical somatosensory evoked potential (CSEP), spinal somatosensory evoked potential (SSEP), and electroencephalogram were recorded in rats under pentobarbital anesthesia. After baseline recordings in room air (21% O2), animals were subjected to a graded hypoxia at 15.75%, 10.5%, and 5.25% oxygen levels for 10 minutes. Each level of hypoxia was followed by a 15-minute reoxygenation period. With a moderate hypoxia (15.75% O2), measured latencies for the CSEP and the SSEP were not significantly different compared with baseline (p greater than 0.05). The CSEP amplitude showed a significant increase (p = 0.02) during reoxygenation after the moderate hypoxia. Change in the latency or amplitude of SSEP at 15.75% hypoxia or during the reoxygenation period was not significant compared with the room air (p greater than 0.05). No change in the electroencephalogram was noticed with the moderate hypoxia. At severe hypoxia (10.5% O2), 80% of the animals lost CSEP within 2 minutes. The loss of CSEP was concomitant with significant attenuation of the electroencephalogram waves. The SSEP was resistant to the severe hypoxia and was present in all animals. We concluded that hypoxia affects CSEP with the tendency to increase the amplitude at moderate hypoxia (15.75%) and loss of the latency and amplitude with severe (10.5%) and extreme (5.25%) hypoxia.
S S Haghighi; J J Oro; S R Gibbs; M McFadden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  37     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-5     Citation Subset:  IM    
Division of Neurosurgery, University of Missouri Hospital and Clinics, Columbia 65212.
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MeSH Terms
Anoxia / physiopathology*
Cerebral Cortex / physiopathology*
Evoked Potentials, Somatosensory*
Rats, Inbred Strains
Spinal Cord / physiopathology*

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