Document Detail

Effect of graded hemorrhage on renal cortical perfusion in dogs.
MedLine Citation:
PMID:  6779654     Owner:  NLM     Status:  MEDLINE    
Renal cortical tissue gas tensions, systemic oxygen supply and some features of energy metabolism and central hemodynamics were recorded in splenectomized dogs during graded hemorrhage and subsequent reinfusion of shed blood. Renal cortical partial pressure of oxygen and carbon dioxide responded rapidly to changes in blood volume and cardiac output. Lowest cortical partial pressure of oxygen values and highest cortical partial pressure of carbon dioxide levels were achieved at a maximal 50 percent blood loss. The decrease in arterial pressure, blood hemoglobin and hematocrit as well as the increase in blood lactate concentration lagged behind blood loss. Renal cortical partial pressure of oxygen, arterial pressure and cardiac output responded rapidly to reinfusions of withdrawn blood, while the cortical partial pressure of carbon dioxide, heart rate, arterial pH and blood lactate concentration returned to initial levels more slowly. Arterial blood gases remained normal throughout the observation period and did not provide an adequate index of tissue oxygenation. In contrast, the partial pressure of oxygen of the renal cortex proved an excellent and sensitive indicator of renal perfusion during hemorrhagic shock and its management.
O Nelimarkka; L Halkola; J Niinikoski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of surgery     Volume:  141     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Volume
Carbon Dioxide
Cardiac Output
Hemoglobins / analysis
Kidney Cortex / blood supply*
Kidney Failure, Acute / etiology
Partial Pressure
Shock, Hemorrhagic / physiopathology*
Spleen / physiology
Reg. No./Substance:
0/Hemoglobins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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