Document Detail

Effect of graded administration of PEEP on lung water in noncardiogenic pulmonary edema.
MedLine Citation:
PMID:  6749435     Owner:  NLM     Status:  MEDLINE    
The effect of graded application of positive end-expiratory pressure (PEEP) was studied in 10 mongrel dogs with pulmonary edema induced by oleic acid infusion. Six animals received progressive increases in PEEP (5 cm H2O) 120 min after the injection of oleic acid. These animals were compared to 4 control animals who did not receive PEEP. We found no difference between the 2 groups in lung water measured by a double indicator dilution technique during PEEP application. Lung water determined by gravimetric analysis was also not different between groups at the end of the experiment. PEEP did result in significant reductions in shunt fraction and alveolar-arterial oxygen tension difference suggesting that PEEP improves gas exchange in pulmonary edema by increasing lung volume, but not by altering lung water accumulation.
G M Saul; T W Feeley; F G Mihm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  10     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-9     Citation Subset:  AIM; IM    
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MeSH Terms
Body Water / metabolism*
Indicator Dilution Techniques
Lung / metabolism*
Models, Biological
Oleic Acid
Oleic Acids
Positive-Pressure Respiration*
Pulmonary Edema / chemically induced,  therapy*
Reg. No./Substance:
0/Oleic Acids; 112-80-1/Oleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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