| Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | |
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MedLine Citation:
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PMID: 9232775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single intraperitoneal dose (25 mg/kg) of gossypol given to male Sprague-Dawley rats caused marked changes in the activity of the hepatic and serum gamma-glutamyltransferase (GGT) and microsomal monooxygenases. The GGT activity in liver homogenate, S-9 supernatant fraction and microsomes was significantly depressed; however, the level of serum GGT was elevated. While the hepatic glutathione concentration was not greatly changed, the aminopyrine N-demethylase activity and microsomal cytochrome P450 content of the liver were significantly decreased in the treated rats. At necropsy, the livers of the treated rats appeared generally pale with distinct pinpoint foci. Histopathological examination of the liver showed degenerative changes and coagulative necrosis. The results indicate that gossypol is a strong hepatotoxic agent which can produce severe hepatic damage. |
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Authors:
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D P Deoras; P Young-Curtis; R R Dalvi; F E Tippett |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Veterinary research communications Volume: 21 ISSN: 0165-7380 ISO Abbreviation: Vet. Res. Commun. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-09-11 Completed Date: 1997-09-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100520 Medline TA: Vet Res Commun Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 317-23 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, School of Veterinary Medicine, Tuskegee University, AL 36088, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminopyrine N-Demethylase
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drug effects,
metabolism Animal Feed Animals Cytochrome P-450 Enzyme System / drug effects, metabolism Glutathione / drug effects, metabolism Gossypol / adverse effects, pharmacology* Infusions, Parenteral Liver / enzymology* Male Microsomes, Liver / drug effects, enzymology* Necrosis Rats Rats, Sprague-Dawley gamma-Glutamyltransferase / drug effects*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1G12RRO3059/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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303-45-7/Gossypol; 70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.5.3.-/Aminopyrine N-Demethylase; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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