Document Detail


Effect of gonadotrophin priming on in-vitro maturation of oocytes collected from women at risk of OHSS.
MedLine Citation:
PMID:  16984762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of human menopausal gonadotrophin (HMG) or human chorionic gonadotrophin (HCG) priming on cumulus-oocyte complex (COC) morphology, oocyte maturation and embryo development in patients undergoing in-vitro maturation (IVM) cycles. The patients were primed with nothing (group 1), low-dose HMG (group 2) or 10,000 IU HCG (group 3) before oocyte retrieval. COC with dispersed cumulus cell appearance was only observed in group 3. In addition, 11% of metaphase II stage oocytes at the time of retrieval were collected from group 3. Oocyte maturation in vitro in group 3 was faster than that in groups 1 and 2. The blastocyst development rate of residual embryos after embryo transfer in group 3 was significantly higher than that of groups 1 and 2 (P < 0.05). These results suggest that HCG priming may stimulate the COC, promote oocyte maturation, and improve developmental competence in IVM cycles.
Authors:
Weon-Young Son; San-Hyun Yoon; Jin-Ho Lim
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  13     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-20     Completed Date:  2006-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  340-8     Citation Subset:  IM    
Affiliation:
Maria Infertility Hospital, Seoul 130-812, Korea. weon-young.son@muhc.mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Gonadotropin / therapeutic use*
Embryo Transfer
Female
Fertilization in Vitro
Humans
Menotropins / therapeutic use*
Oocyte Donation / methods*
Oocytes / physiology*
Ovarian Hyperstimulation Syndrome / prevention & control*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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