Document Detail

Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency.
MedLine Citation:
PMID:  17965964     Owner:  NLM     Status:  MEDLINE    
Growth hormone deficiency (GHD) in adult patients is associated with marked decrease in bone turnover, low bone mass and high risk of clinical and subclinical fractures. We investigated whether the prevalence of spinal deformities in adults with GHD was related to the gonadal status of patients. A total of 89 adult hypopituitary patients with severe GHD were evaluated for bone mineral density (BMD) and vertebral deformities (quantitative morphometric analysis). At the study entry, 54 patients were eugonadic whereas 35 patients were hypogonadic without replacement treatment. Radiological spinal deformities were found in 55 patients (61.8%) with higher prevalence in untreated (56 cases) versus treated (33 cases) GHD patients. Eugonadic and hypogonadic patients showed no significant difference in spinal deformities although T-score was significantly lower in hypogonadic as compared with eugonadic patients. Gonadal function was not correlated with the occurrence of spinal deformities which was instead inversely correlated with rhGH treatment. In conclusion, gonadal status may influence BMD in adult patients with GHD without affecting the risk to develop vertebral deformities. Conversely, rhGH replacement treatment seems to be the only factor influencing the risk to develop vertebral deformities in adult GHD patients.
Gherardo Mazziotti; Antonio Bianchi; Vincenzo Cimino; Stefania Bonadonna; Paola Martini; Alessandra Fusco; Laura De Marinis; Andrea Giustina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pituitary     Volume:  11     ISSN:  1573-7403     ISO Abbreviation:  Pituitary     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-28     Completed Date:  2009-06-11     Revised Date:  2009-06-26    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Endocrine Section, Department of Internal Medicine, University of Brescia, 2 Medicina-Spedali Civili, Brescia 25125, Italy.
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MeSH Terms
Absorptiometry, Photon*
Aged, 80 and over
Bone Density* / drug effects
Cross-Sectional Studies
Hormone Replacement Therapy
Human Growth Hormone / deficiency*,  therapeutic use
Hypogonadism / blood,  etiology*,  prevention & control,  radiography
Hypopituitarism / blood,  complications*,  drug therapy,  radiography
Middle Aged
Recombinant Proteins / therapeutic use
Risk Assessment
Risk Factors
Severity of Illness Index
Spinal Diseases / blood,  etiology*,  prevention & control,  radiography
Spinal Fractures / etiology,  prevention & control,  radiography
Spine / drug effects,  radiography*
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Recombinant Proteins; 12629-01-5/Human Growth Hormone

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