Document Detail

Effect of glycomacropeptide fractions on cholecystokinin and food intake.
MedLine Citation:
PMID:  20205966     Owner:  NLM     Status:  MEDLINE    
Glycomacropeptide (GMP) is the hydrophilic 64-amino acid C-terminal glycopeptide released into cheese whey when kappa-casein is cleaved by chymosin. GMP exists as a mixture of different glycoforms due to the carbohydrates sialic acid (N-acetylneuraminic acid, NeuNAc), galactose (Gal), galactosamine and glucosamine attached by O-glycosidic linkages. GMP reportedly stimulates the release of cholecystokinin (CCK), which may promote satiety. The objectives of the present study were to manufacture three glycoforms of GMP, minimally glycosylated GMP (3.5 (sd 0.1) % NeuNAc and 1.5 (sd 0.1) % Gal), glycosylated GMP (12.0 (sd 0.3) % NeuNAc and 4.2 (sd 0.2) % Gal) and a GMP-depleted whey protein concentrate, and to assess the effects of these fractions relative to glucose on CCK, subjective measures of satiety and food intake. In a randomised double-blind acute study, twenty overweight/obese males (56.9 (sd 7.2) years, 97.4 (sd 8.1) kg, 31.5 (sd 3.0) kg/m2) were recruited to consume four 50 g preloads (two GMP preparations, GMP-depleted whey and glucose) containing 895 kJ. Blood samples and subjective measures of satiety were collected before and at 15, 30, 60, 90, 120 and 180 min after the consumption of preload, and CCK levels were measured. A lunchtime meal of hot food was provided from which subjects ate ad libitum until satisfied. Energy and nutrient intakes from the food consumed were calculated. There was no significant difference in CCK levels, subjective measures of satiety or food intake between treatments at the given preload level. These results suggest that the protein fractions at the dose employed do not influence satiety, CCK levels or energy intake at a subsequent meal.
Jennifer B Keogh; Brad W Woonton; Cheryl M Taylor; Filip Janakievski; Kirthi Desilva; Peter M Clifton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-03-08
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  286-90     Citation Subset:  IM    
CSIRO Preventative Health Flagship, Food and Nutritional Sciences, Kintore Avenue, Adelaide SA 5000, Australia.
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MeSH Terms
Appetite Regulation / drug effects,  physiology
Caseins / pharmacology*
Cholecystokinin / blood*
Double-Blind Method
Eating / drug effects*
Middle Aged
Obesity / metabolism
Overweight / metabolism*
Peptide Fragments / pharmacology*
Satiation / drug effects*
Time Factors
Young Adult
Reg. No./Substance:
0/Caseins; 0/Peptide Fragments; 0/caseinomacropeptide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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