Document Detail

Effect of glycochenodeoxycholic acid on unidirectional transepithelial fluxes of electrolytes in the perfused human ileum.
MedLine Citation:
PMID:  847387     Owner:  NLM     Status:  MEDLINE    
Perfusion studies of the terminal ileum were performed in healthy volunteers to define the influence of a dihydroxy bile acid, glycochenodeoxycholic acid (GCDC) 2.5 mmol/l, on the mechanisms of electrolyte transport. Net movements of water and electrolytes, bidirectional fluxes of sodium, potassium, and chloride, and the transmural electrical potential difference (PD) were measured simultaneously. The results supported the notion of an active mechanism for sodium and chloride transfer. GCDC evoked net secretion of water and electrolytes, and decreased the mucosa to serosa flux of chloride, There was a tendency that the latter also applied to sodium and potassium. During bile acid perfusion active secretion of chloride occurred. PD was 16 +/- 4 mV, lumen negative, and was not influenced by GCDC. In conclusion, we propose a model for the GCDC effect.
E Oddsson; J Rask-Madsen; E Krag
Related Documents :
3338647 - Hepatic handling of a synthetic gamma-labeled bile acid (75sehcat).
12606307 - Bile acids activate egf receptor via a tgf-alpha-dependent mechanism in human cholangio...
2407297 - Cholesterol 7 alpha-hydroxylase activity and bile acid synthesis in hepatocytes of unwe...
7981417 - Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate...
2210237 - Phospholipids from rat, human, and canine gastric mucosa. composition and metabolism of...
6438077 - Association of apolipoprotein a-ii with egg phosphatidylcholine unilamellar vesicles.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  12     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1977  
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Transport, Active / drug effects
Cell Membrane Permeability / drug effects
Chenodeoxycholic Acid / pharmacology*
Ileum / metabolism
Intestinal Mucosa / metabolism
Intestine, Small / metabolism*
Sodium / metabolism*
Water-Electrolyte Balance / drug effects
Reg. No./Substance:
474-25-9/Chenodeoxycholic Acid; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Marital status and sexual adjustment after colectomy. Results in 178 patients operated on for ulcera...
Next Document:  Renal extraction of endogenous gastrin in patients with normal renal function.