Document Detail


Effect of glycine on tissue fatty acid composition in an experimental model of alcohol-induced hepatotoxicity.
MedLine Citation:
PMID:  15236634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The aim of the present study was to investigate the effect of the administration of glycine, a non-essential amino acid, on blood alcohol levels and tissue fatty acid composition in experimental rats. 2. Liver cell damage was induced by the administration of ethanol (7.9 g/kg bodyweight) for 30 days by intragastric intubation. Control rats were given isocaloric glucose solution. Glycine was subsequently administered at a dose of 0.6 g/kg bodyweight every day by intragastric intubation for the next 30 days. 3. Feeding alcohol significantly elevated the activities of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatases (ALP) and gamma-glutamyl transpeptidase (GGT) and altered the liver and brain fatty acid composition compared with control rats. Subsequently, glycine supplementation to alcohol-fed rats significantly lowered the activities of serum AST, ALT, ALP, GGT and normalized the liver and brain fatty acid composition compared with untreated alcohol-fed rats. 4. Thus, the present study demonstrates that oral administration of glycine confers a significant protective effect against alcohol-induced hepatotoxicity by virtue of its ability to optimize the activities of serum AST, ALT, ALP and GGT, as well as the tissue fatty acid composition.
Authors:
Rajagopal Senthilkumar; Namasivayam Nalini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  31     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-06     Completed Date:  2005-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  456-61     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry / drug effects
Ethanol / blood
Fatty Acids / metabolism*
Glycine / pharmacology*
Hepatitis, Alcoholic / enzymology,  metabolism*
Liver / metabolism
Liver Function Tests
Male
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Fatty Acids; 56-40-6/Glycine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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