Document Detail

Effect of glycerol, mannitol, and lasix on cerebrospinal fluid pressure in the acute period of a stroke
MedLine Citation:
PMID:  6797162     Owner:  NLM     Status:  MEDLINE    
On giving a dose of glycerol (orally), mannitol or lasix (intravenously) to patients with a cerebral stroke in the acute period the cerebrospinal fluid (CSF) pressure in them dropped, on the average, by 70-80%, 65-70%, and 25-30%, respectively. However in 6.5 to 7.5 hours it rose again and the after-effect phenomenon appeared. The effects of the drugs having been over, the CSF pressure was found to exceed the initial level by 50-60% after the glycerol intake; by 75 to 80% after the mannitol, an by 4 to 6% after the lasix injections. When glycerol, mannitol, and lasix were given rectally the CSF pressure dropped, respectively, by 35-45%, 35-40%, and 20-25% below the initial level, and did not rise throughout the whole period of the observation.
N S Misiuk; V I Kurgaev
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)     Volume:  81     ISSN:  0044-4588     ISO Abbreviation:  Zh Nevropatol Psikhiatr Im S S Korsakova     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710066     Medline TA:  Zh Nevropatol Psikhiatr Im S S Korsakova     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  1149-52     Citation Subset:  IM    
Vernacular Title:
O vliianii glitserina, mannitola i laziksa na likvornoe davlenie v ostrom periode pozgovogo insul'ta.
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MeSH Terms
Acute Disease
Brain Edema / prevention & control*
Brain Ischemia / cerebrospinal fluid,  drug therapy*
Cerebral Hemorrhage / cerebrospinal fluid,  drug therapy*
Furosemide / therapeutic use*
Glycerol / therapeutic use*
Intracranial Pressure
Mannitol / therapeutic use*
Reg. No./Substance:
54-31-9/Furosemide; 56-81-5/Glycerol; 69-65-8/Mannitol

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