| Effect of glycerol feeding on endurance and metabolism during prolonged exercise in man. | |
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MedLine Citation:
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PMID: 6353128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the effectiveness of pre-exercise glycerol feeding in protecting against development of hypoglycemia and sparing muscle glycogen during prolonged, intense exercise. Thirty minutes after ingesting either glycerol (1 gm X kg-1 body weight) or a placebo, 10 cyclists performed as much exercise on a cycle ergometer as they were able in 150 min. The average exercise intensity was 72% of VO2max during both trials. Glycerol ingestion increased blood glycerol concentration 100-fold, but did not alter the respiratory exchange ratio (R), plasma levels of insulin and free-fatty acids, or blood lactate and beta-hydroxybutyrate. The only significant effect of glycerol feeding was to postpone the decline in blood glucose by about 30 min. This suggests that glycerol served, to a limited extent, as a gluconeogenic substrate; however, glycerol ingestion did not spare muscle glycogen during 90 min of treadmill exercise at 71% VO2max. It appears that man cannot utilize glycerol as gluconeogenic substrate rapidly enough to serve as a major energy source during strenuous exercise. |
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Authors:
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J M Miller; E F Coyle; W M Sherman; J M Hagberg; D L Costill; W J Fink; S E Terblanche; J O Holloszy |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 15 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 1983 |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 237-42 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Clinical Trials as Topic Double-Blind Method Exercise Test* Female Glycerol / administration & dosage, pharmacology* Glycogen / metabolism* Humans Hypoglycemia / prevention & control Male Muscles / metabolism* Physical Endurance / drug effects* Random Allocation Sports Medicine* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG00078/AG/NIA NIH HHS; HL07081/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-81-5/Glycerol; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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