| Effect of glutamine in short-bowel syndrome. | |
| | |
MedLine Citation:
|
PMID: 11478829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Animal studies have reported positive effects of glutamine on intestinal absorption and morphology; human studies have been less convincing. The aim of this study was to evaluate the effects of glutamine and diet on intestinal morphology, motility, and absorption. METHODS: A randomized, double blind, placebo-controlled crossover study in 8 patients with short-bowel on a high carbohydrate, low fat (HCLF) diet, was performed. Active treatment was oral glutamine (0.45 g kg(-1)day(-1)) for eight weeks. Intestinal morphology was evaluated by light microscopy. Gastrointestinal transit was measured by dual gamma camera scintigraphy. D-xylose and fecal fat collection was used to evaluate intestinal absorption. Results of active treatment versus placebo were compared by the signed-rank test. RESULTS: Morphology analysis, reported as median active treatment versus placebo, was villus height: 0.48 mm versus 0.50 mm, P=1.0, and crypt depth: 0.11 mm versus 0.10 mm, P=0.469. Percent D-xylose absorption, reported as median active treatment versus placebo, was 7% versus 10.5%, P=0.109. There was not a significant difference in wet weight or fat absorption compared to placebo, P>0.05. Likewise, gastrointestinal transit was not different compared to placebo. CONCLUSIONS: The results of this controlled study would support that 8 weeks of treatment with oral glutamine and a HCLF diet does not significantly improve intestinal morphology, gastrointestinal transit, D-xylose absorption and stool losses in short bowel patients. |
| | |
Authors:
|
J S Scolapio; K McGreevy; G S Tennyson; O L Burnett |
Related Documents
:
|
19660909 - Pretreatment with arginine preserves intestinal barrier integrity and reduces bacterial... 15539269 - Effects of dietary polyamines and clofibrate on metabolism of polyamines in the rat. 7570589 - Activation of ornithine decarboxylase in epithelial cells of rat intestine. 20144729 - Dietary protein hydrolysates and free amino acids affect the spatial expression of pept... 2512599 - Effects of age and diet on small intestinal structure and function in gnotobiotic piglets. 7063809 - Influence of fasting on intestinal permeability and disease activity in patients with r... 8157529 - Growth and reproductive development in brahman bulls fed diets containing gossypol. 3476969 - Do endogenous lipoproteins modulate the sensibility of animals against arrhythmogenic d... 20416639 - Effects of chestnut tannins on carcass characteristics, meat quality, lipid oxidation a... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: 20 ISSN: 0261-5614 ISO Abbreviation: Clin Nutr Publication Date: 2001 Aug |
Date Detail:
|
Created Date: 2001-07-31 Completed Date: 2001-11-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: Scotland |
Other Details:
|
Languages: eng Pagination: 319-23 Citation Subset: IM |
Copyright Information:
|
Copyright 2001 Harcourt Publishers Ltd. |
Affiliation:
|
Division of Gastroenterology and Hepatology, Mayo Clinic Jacksonville, Florida 32224, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cross-Over Studies Feces / chemistry Female Gastrointestinal Motility / drug effects* Gastrointestinal Transit Glutamine / pharmacology* Humans Intestinal Absorption / drug effects* Intestines / pathology* Male Middle Aged Short Bowel Syndrome / drug therapy*, physiopathology Xylose / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
|
0/Xylose; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytokine-mediated inhibition of ketogenesis is unrelated to nitric oxide or protein synthesis.
Next Document: Effect of fasting on rat duodenal and jejunal microvilli.