| Effect of a glutamine-enriched diet on small bowel allograft during immunosuppressive therapy. | |
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MedLine Citation:
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PMID: 9290090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of an orally administered glutamine-enriched elemental diet was examined following orthotopic small bowel allotransplantation using Brown Norway rats as donors and Lewis rats as recipients. The recipients was treated with FK 506 and randomized to receive glutamine-free elemental enteral diet solution (glutamine-free group), glutamine-enriched elemental diet solution containing 7500 mg of glutamine per 100 g diet (glutamine-enriched group) or standard chow (chow group) ad libitum for 7 d. There were no histological changes due to resection. Weight loss in the glutamine-enriched group was significantly less than that of the chow group. Both plasma glutamine levels and the ratio of glutamine to total amino acids in the homogenate of the graft mucosa of the glutamine-enriched group were significantly higher than those of the glutamine-fee group. Villous height and crypt depth were significantly decreased in the glutamine-free group. The BrdU labeling index in the graft epithelium and alkaline phosphatase activity in the homogenate of the graft mucosa of the glutamine-enriched group were significantly higher than those of the glutamine-free group. Therefore, orally administered glutamine-enriched elemental diet appears to promote the regeneration and differentiation of the graft mucosa following small bowel allotransplantation. |
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Authors:
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M Yagi; K Sakamoto; K Hasebe; H Ito; I Onishi; T Tani; T Hashimoto; K Shimizu; K Miwa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 13 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-17 Completed Date: 1997-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 778-82 Citation Subset: IM |
Affiliation:
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Department of Surgery II, School of Medicine, Kanazawa University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Alanine / analysis, blood, metabolism Alkaline Phosphatase / analysis, metabolism Ammonia / analysis, blood, metabolism Animals Body Weight / drug effects, physiology Bromodeoxyuridine / analysis Cell Division / physiology Diet Epithelial Cells / cytology, drug effects Glutamic Acid / blood, metabolism Glutamine / administration & dosage, blood, pharmacology* Immunosuppression / methods* Immunosuppressive Agents / pharmacology Intestinal Mucosa / chemistry, cytology, drug effects Intestine, Small / chemistry, drug effects*, transplantation* Male Microvilli / ultrastructure Random Allocation Rats Rats, Inbred BN Rats, Inbred Lew Tacrolimus / pharmacology Time Factors Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 56-41-7/Alanine; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 59-14-3/Bromodeoxyuridine; 7664-41-7/Ammonia; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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