| Effect of glucose-insulin-potassium infusions on epicardial ECG changes and on myocardial metabolic changes after coronary artery ligation in dogs. | |
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MedLine Citation:
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PMID: 7032699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of glucose-insulin-potassium infusion (GIK) on developing myocardial infarction in dogs was evaluated, commencing infusion 30 min after coronary artery ligation (CAL). The parameters studied were: early (60 min after CAL) and late (6 and one half h after CAL) epicardial ST segment elevation, the change in Q, R, and S waves and certain myocardial metabolic determinations (glycogen, sodium, potassium, dry-wet weight ratio, adenosine triphosphate, creatine phosphate, inorganic phosphate, and lactate). 6 and one half h after coronary ligation Q wave amplitude was less, the R wave amplitude was greater and the metabolic profile in hte infarct zone was less deranged; metabolic improvement was also found in the nonischaemic zone. Sites in which early ST-segment elevation was less with GIK did not predict all the sites in which there was eventual lessened Q wave formation. R wave fall and disturbance of myocardial metabolism. This study supports others showing an effect of GIK in improving the features of developing experimental myocardial infarction. Following the rate of Q wave development in relation to the early ST segment elevation may be of value in assessing GIK effects provided that a qualitative rather than quantitative relationship between the two parameters is accepted. |
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Authors:
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A J Dalby; O L Bricknell; L H Opie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 15 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1982-03-22 Completed Date: 1982-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 588-98 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Drug Combinations Electrocardiography Glucose / pharmacology, therapeutic use* Heart / drug effects, physiopathology Insulin / pharmacology, therapeutic use* Myocardial Infarction / drug therapy* Myocardium / metabolism Potassium / pharmacology Sodium / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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