| Effect of glucose control on lipid levels in patients with type 2 diabetes | |
| | |
MedLine Citation:
|
PMID: 11987016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVE: The dyslipoproteinemia characterizing patients with type 2 diabetes is a major risk factor for atherosclerosis. Prospective studies indicate that an improved glucose control is associated with lower lipid levels. In this study we evaluated whether an improvement of the lipid status can also be observed in a routine clinical setting. Furthermore, we evaluated how many patients achieve lipid target levels by improving glucose control. METHODS: In 51 type 2 diabetics (60 +/- 12 ys., 29 men, 22 women) lipid values were determined before and after improvement of glucose metabolism (6 - 12 weeks, HbA1c 7.9 +/- 1.9 % vs. 7.1 +/- 1.3 %). Patients on lipid-lowering medication or with atherosclerosis were excluded. The improved glucose control was achieved by starting/intensifying treatment with diet (n = 5), acarbose (n = 5), metformin (n = 10), sulfonylurea/glinide (n = 12) or insulin (n = 19). RESULTS: The decrease in HbA1c was associated with a decrease in total cholesterol (232 +/- 64 vs. 216 +/- 35 mg/dl, p < 0.05) and triglycerides (348 +/- 448 vs. 216 +/- 139 mg/dl, p < 0.01), while HDL- and LDL-cholesterol did not change significantly. Only in patients with triglycerides > 200 mg/dl did changes in HbA1c-levels correlate with changes in triglyceride-levels (r(2) = 0.32, p = 0.012). Lipid target levels were reached in seven of 51 patients (five of 51 patients before improvement of HbA1c). CONCLUSION: Although in routine clinical practice an improvement in HbA1c results in better lipid values. This improvement is small and is usually not sufficient to reach lipid target levels. |
| | |
Authors:
|
K G Parhofer; E Laubach; H C Geiss; C Otto |
Publication Detail:
|
Type: English Abstract; Evaluation Studies; Journal Article |
Journal Detail:
|
Title: Deutsche medizinische Wochenschrift (1946) Volume: 127 ISSN: 0012-0472 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-05-02 Completed Date: 2002-06-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
|
Languages: ger Pagination: 958-62 Citation Subset: IM |
Affiliation:
|
Medizinische Klinik II, Grosshadern, Klinikum der Ludwig-Maximilians Universität München, Germany. parhofter@med2.med.uni-muenchen.de |
Vernacular Title:
|
Einfluss einer verbesserten Blutzuckereinstellung auf den Lipidspiegel bei Patienten mit Typ-2-Diabetes. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Blood Glucose / metabolism* Cholesterol / blood Combined Modality Therapy Diabetes Mellitus, Type 2 / blood, therapy* Diabetic Diet* Female Hemoglobin A, Glycosylated / metabolism* Humans Hyperlipidemias / blood, therapy* Hypertriglyceridemia / blood, therapy* Hypoglycemic Agents / therapeutic use* Male Middle Aged Retrospective Studies Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictors of abnormal glucose tolerance in persons at risk of type 2 diabetes: the RIAD study
Next Document: Dietary modulation of circulating leptin levels: site-specific changes in fat deposition and ob mRNA...