Document Detail

Effect of glucocorticoids and zinc deficiency on femur and liver zinc in rats.
MedLine Citation:
PMID:  430248     Owner:  NLM     Status:  MEDLINE    
Male weanling rats were fed diets containing less than 1, 3, 6 oor 13 ppm zinc or stock rat diet for 3 weeks. Each dietary group was subdivided into a control group and a prednisolone-treated group (5 mg pred/kg body weight). Femur and liver zinc contents were determined by flame atomic absorption spectrophotometry. Prednisolone caused growth retardation at all levels of dietary zinc. A marked increase was seen in femur zinc content of prednisolone-treated rats fed zinc-deficient diets. No such increase was seen in rats fed diets adequate in zinc. No significant change was seen in liver zinc content of zinc-deficient rats due to prednisolone. By comparing femur zinc in rats fed zinc-deficient diets with femur zinc in weanling rats, it appears that prednisolone causes an increase in femur zinc in rats fed deficient diets by (a) preventing bone resorption, and (b) increasing femur uptake of dietary zinc. Because the effects of glucocorticoids in rats appear to differ from effects in man, similar studies in other species are recommended.
J Turnlund; S Margen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  109     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
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MeSH Terms
Bone and Bones / metabolism*
Femur / metabolism
Liver / metabolism*
Prednisolone / pharmacology*
Zinc / deficiency,  metabolism*
Reg. No./Substance:
50-24-8/Prednisolone; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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