Document Detail


Effect of glucocorticoids and zinc deficiency on femur and liver zinc in rats.
MedLine Citation:
PMID:  430248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male weanling rats were fed diets containing less than 1, 3, 6 oor 13 ppm zinc or stock rat diet for 3 weeks. Each dietary group was subdivided into a control group and a prednisolone-treated group (5 mg pred/kg body weight). Femur and liver zinc contents were determined by flame atomic absorption spectrophotometry. Prednisolone caused growth retardation at all levels of dietary zinc. A marked increase was seen in femur zinc content of prednisolone-treated rats fed zinc-deficient diets. No such increase was seen in rats fed diets adequate in zinc. No significant change was seen in liver zinc content of zinc-deficient rats due to prednisolone. By comparing femur zinc in rats fed zinc-deficient diets with femur zinc in weanling rats, it appears that prednisolone causes an increase in femur zinc in rats fed deficient diets by (a) preventing bone resorption, and (b) increasing femur uptake of dietary zinc. Because the effects of glucocorticoids in rats appear to differ from effects in man, similar studies in other species are recommended.
Authors:
J Turnlund; S Margen
Related Documents :
20887308 - Determination of true absorption and fecal endogenous loss of zinc in goats.
6695828 - Studies of marginal zinc deprivation in rhesus monkeys. i. influence on pregnant dams.
1172928 - Increased susceptibility to pulmonary oxygen toxicity after cholesterol biosynthesis in...
3798368 - 6-mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat.
14988078 - Subcutaneous obesity is not associated with sympathetic neural activation.
18034758 - The effect of frequency of consumption of artificial sweeteners on sweetness liking by ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  109     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bone and Bones / metabolism*
Diet
Femur / metabolism
Liver / metabolism*
Male
Prednisolone / pharmacology*
Rats
Zinc / deficiency,  metabolism*
Chemical
Reg. No./Substance:
50-24-8/Prednisolone; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The preferential transport of immunoglobulin G by the small intestine of the neonatal piglet.
Next Document:  Effect of feeding 1,3-butanediol-1,3-dioctanoate as an energy source for chicks for catch-up growth ...