| Effect of glucagon on glucose output from bivascularly perfused rat liver. | |
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MedLine Citation:
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PMID: 2630315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucose output was investigated in bivascularly perfused rat liver. Flow rate was 1 ml/min/g from hepatic artery and 2 ml/min/g from portal vein. Basal glucose output (130 +/- 30 microM/min) from bivascularly perfused liver was significantly (p less than 0.02) higher than that (80 +/- 20 microM/min) from usual monovascularly perfused (3 ml/min/g from portal vein) liver. However, glucagon-induced (1 ng/ml) increment in glucose output from bivascularly perfused liver 589 +/- 127 microM/30 min) was not significantly different from that (630 +/- 127 microM/30 min) of monovascularly perfused liver. These results suggest that glucagon-dependent glucose output was similar in monovascularly and bivascularly perfused rat liver, and that arterial blood supply may have some role in glycogenolysis in the perfused rat liver. |
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Authors:
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T Ikeda; T Hoshino; M Honda; T Takeuchi; O Mokuda; M Tominaga; H Mashiba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental and clinical endocrinology Volume: 94 ISSN: 0232-7384 ISO Abbreviation: Exp. Clin. Endocrinol. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-05-01 Completed Date: 1990-05-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302802 Medline TA: Exp Clin Endocrinol Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 383-6 Citation Subset: IM |
Affiliation:
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The First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucagon / pharmacology* Glucose / metabolism* Liver / metabolism* Male Perfusion Portal Vein Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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