Document Detail

Effect of glucagon on arrhythmias induced by coronary artery occlusion and ouabain in dogs.
MedLine Citation:
PMID:  7216388     Owner:  NLM     Status:  MEDLINE    
The effect of glucagon in arrhythmias induced by coronary artery occlusion and ouabain was studied in dogs. Intravenous administration of glucagon (50 microgram/kg) to 6 dogs with more than 70% ectopic activity after coronary artery occlusion, resulted in significant (P less than 0.01) decrease in ectopics and increase in heart rate. Infusion of glucagon (2.5 microgram/kg/min) for 30 min caused complete elimination of ectopic activity during infusion period. In another series of 7 experiments, glucagon failed to abolish the ouabain-induced ectopic beats. In fact the hormone itself caused a significant (P less tha 0.01) increase in ectopic activity and heart rate. However, in 7 dogs with complete heart block produced after ouabain conversion to normal sinus rhythm was observed after glucagon.
J Singh; S Bala; A H Kaur; K N Garg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  24     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1980 Oct-Dec
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
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MeSH Terms
Anti-Arrhythmia Agents*
Arrhythmias, Cardiac / chemically induced,  etiology,  physiopathology
Coronary Vessels / physiology
Glucagon / pharmacology*
Heart Rate / drug effects
Ouabain / pharmacology
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 630-60-4/Ouabain; 9007-92-5/Glucagon

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