Document Detail

Effect of glove occlusion on human skin (II). Long-term experimental exposure.
MedLine Citation:
PMID:  8730163     Owner:  NLM     Status:  MEDLINE    
Gloves are indispensable in many occupations. Irritant skin reactions from gloves have, however, been reported. In the present study, the effect of long-term glove occlusion on normal skin (6 h/day for 14 days) was studied and, in addition, the effect of a cotton glove worn under the occlusive glove was also studied. 2 studies were performed (studies A and B). Study A: 19 volunteers wore an occlusive glove on normal skin 6 h/day for 14 days. They wore the glove on one hand only, while the other hand served as control. Study B: 18 volunteers wore occlusive gloves on both hands on normal skin. A cotton glove was worn under the occlusive glove on either the left or the right hand. Skin barrier function was evaluated by measurement of transepidermal water loss (TEWL) (Evaporimeter), skin hydration by electrical capacitance (Corneometer) and inflammation by erythema index (Derma-Spectrometer). The gloves used were hypoallergenic non-latex gloves. Results. Study A: glove occlusive on normal skin 6 h/day for 14 days had a significant negative effect on skin barrier function, as measured by TEWL. Study B: the negative effect on skin barrier function from occlusive gloves was prevented by the use of a cotton glove. It is concluded that gloves may be a substantial factor in the pathogenesis of cumulative irritant contact dermatitis, and that recommendations as to their use are important.
D W Ramsing; T Agner
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Contact dermatitis     Volume:  34     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-17     Completed Date:  1996-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  IM    
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Dermatitis, Allergic Contact / etiology,  physiopathology*
Electric Impedance
Gloves, Protective / adverse effects*
Hand Dermatoses / etiology,  physiopathology*
Middle Aged
Skin Physiological Phenomena*
Water Loss, Insensible / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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