| Effect of gestational zinc deficiency on pregnancy outcomes: summary of observation studies and zinc supplementation trials. | |
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MedLine Citation:
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PMID: 11509097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lack of a valid indicator precludes a true estimate of zinc deficiency in pregnancy in various populations. However, it is possible that mild to moderate deficiency (as assessed by available indicators) may be common in the developing world. Animal experiments indicate that zinc deficiency can result in adverse maternal and fetal consequences. Human data, particularly from prenatal zinc supplementation trials, has failed to document a consistent maternal or infant benefit on evaluated outcome measures including pregnancy induced hypertension, preterm/post-term labour, premature rupture of membranes, maternal infection, postpartum haemorrhage, perinatal mortality, congenital malformations and fetal growth and gestation. Preliminary data suggest a beneficial effect of prenatal zinc supplementation on infants' neurobehavioural development and immune function (evaluated by diarrhoeal and ARI morbidity incidence in the first year of life). Future research should focus on these functional consequences and congenital malformations (with adequate sample sizes), and simultaneously address the safety issue, particularly in relation to micronutrient interactions. In the light of the currently available information, routine zinc supplementation can not be advocated to improve pregnancy outcome. |
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Authors:
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D Shah; H P Sachdev |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The British journal of nutrition Volume: 85 Suppl 2 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-08-17 Completed Date: 2001-08-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: S101-8 Citation Subset: IM |
Affiliation:
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Division of Clinical Epidemiology, Department of Pediatrics, Maulana Azad Medical College, New Delhi 110 002, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Infections / immunology Cognition Congenital Abnormalities / etiology Developing Countries* Embryonic and Fetal Development Female Growth Humans Immune System / growth & development Infant, Newborn Pregnancy Pregnancy Complications / drug therapy*, etiology* Pregnancy Outcome Zinc / administration & dosage*, deficiency* |
| Chemical | |
Reg. No./Substance:
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7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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