Document Detail


Effect of gestational age on first trimester maternal serum prenatal screening correction factors for ethnicity and IVF conception.
MedLine Citation:
PMID:  23172419     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study is to investigate gestational age effects of maternal ethnicity and in vitro fertilization (IVF) pregnancy correction factors of first trimester trisomy 21 screening markers pregnancy associated plasma protein A (PAPP-A) and free-β human chorionic gonadotropin (free hCGβ) in a large dataset. METHODS: Data from 205 341 normal singleton pregnancies were retrieved, and PAPP-A and free hCGβ concentrations were converted to multiples of the medians (MoMs) uncorrected for either maternal ethnicity or IVF pregnancy. Log(10) transformed MoMs were plotted against gestational age in each group to examine gestational age effects RESULTS: Significant gestational age effects were found for correction factors for PAPP-A in Afro-Caribbean, South Asian and East Asian, and for free hCGβ in Afro-Caribbean and IVF pregnancy. CONCLUSIONS: Current single correction factors for PAPP-A and free hCGβ based on maternal ethnicity and IVF pregnancy are inappropriate, and future screening algorithms need to take into account the change in effect of these factors with gestational age. © 2012 John Wiley & Sons, Ltd.
Authors:
Nicholas J Cowans; Kevin Spencer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Affiliation:
Prenatal Research Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK.
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