Document Detail

Effect of geometric remodeling on left ventricular longitudinal contractile reserve in patients with hypertension.
MedLine Citation:
PMID:  17658727     Owner:  NLM     Status:  MEDLINE    
Left ventricular hypertrophy (LVH) is associated with a reduction of subendocardial coronary flow reserve, which may be associated with abnormal myocardial longitudinal function during exercise. To test this hypothesis, 182 hypertensive patients underwent multistage supine bicycle exercise testing. Patients were classified as follows: patients with normal geometry (group 1, n = 116), concentric remodeling (group 2, n = 31), or LVH (group 3, n = 31). The results showed that the ratio of E/E', an index of left ventricular (LV) filling pressure, was significantly elevated in the LVH group at rest and during exercise. At rest, the mitral annular systolic velocity (S') was similar between the three groups at rest, whereas S' during exercise was significantly lower in the LVH group. The magnitude of change in S' during exercise was also significantly lower in the LVH group. Multiple linear regression analysis showed that peak double product (beta = 0.208, P = .006) and LV mass index (beta = -0.158, P = .028) were independently associated with LV longitudinal contractile reserve. Also, multiple linear regression analysis showed that changes in S' from baseline to peak were independently associated with exercise duration (beta = 0.123, P = .041) when controlled for age, male gender, baseline E', peak systolic blood pressure, and LV mass index. The results from this study demonstrate that LVH was significantly associated with abnormal LV longitudinal contractile reserve in hypertensive patients.
Sungha Park; Hye-Sun Seo; Chi Young Shim; Eui Young Choi; Young-Guk Ko; Donghoon Choi; Jong-Won Ha; Se-Joong Rim; Namsik Chung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-20
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  21     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Cardiology Division, Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.
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MeSH Terms
Coronary Circulation
Exercise Test
Fractional Flow Reserve, Myocardial*
Hypertension / complications*,  ultrasonography*
Hypertrophy, Left Ventricular / etiology*,  ultrasonography*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Ventricular Dysfunction, Left / etiology*,  ultrasonography*
Ventricular Remodeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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